DRD2, dopamine receptor D2, 1813

N. diseases: 437; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Altogether, the present findings suggested that the ADORA2A gene and the interaction of ADORA2A and DRD2 genes may play a role in anxiety disorders in children and adolescents with ADHD. 30946941 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE We previously reported that dopamine D2 receptor knockout (D2R<sup>-/-</sup>) mice display increased anxiety and depression-like behaviors upon chronic stress. 28912499 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE After adjusting for age, occupation, education, marital status, self-rating anxiety score, and disease status, we observed significant negative associations of catechol-O-methyltransferase (COMT), dopamine receptor D2 (DRD2) gene score and smoking cessation, as well as significant positive associations between ankyrin repeat and kinase domain containing 1 (ANKK1), dopamine transporter (SLC6A3), dopamine receptor D4 (DRD4) gene score and smoking cessation. 27490263 2016
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE It is hypothesized that dopaminergic genes-dopamine type-2 receptor (DRD2), aldehyde dehydrogenase 2 (ALDH2), and catechol-O-methyltransferase (COMT)-are associated with bipolar disorder (BP) and anxiety disorder (AD). 25430946 2015
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Our study also provides further evidence that the ALDH2 and DRD2 genes interact in BP-II, particularly BP-II without AD. 23835015 2014
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE An association was detected between the DRD2 A1 allele and symptoms of depression and anxiety indexed using interview and parent report methods. 20526230 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group CTD_human Genetics of caffeine consumption and responses to caffeine. 20532872 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Findings in DRD2 became stronger when only anxiety disorder cases with comorbid alcohol use disorder were considered. 20122683 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE Caffeine-induced anxiety (VAS) was also associated with two-loci interactions of selected ADORA2A and DRD2 polymorphisms. 18305461 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P=0.004 and P=0.003, and P=0.01 and P=0.005, respectively). 18307984 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group CTD_human Caffeine-induced anxiety (VAS) was also associated with two-loci interactions of selected ADORA2A and DRD2 polymorphisms. 18305461 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate phenotypes including: dopaminergic system polymorphic variants (DRD2 -141C Ins/Del in promoter region, exon 8 and DRD2 TaqI A and DAT 40bp VNTR genes polymorphisms) that cause predisposition to severe alcoholism (haplotype Ins/G/A2); COMT Val158Met gene polymorphism related to differences in executive cognitive function and 5-HTT gene promoter polymorphism, which alters stress response and affects anxiety and dysphoria. 17079080 2006
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE Subjects with the DRD2 Al allele compared to those without this allele had significantly higher scores on GHQ 2 (anxiety/insomnia), GHQ 3 (social dysfunction) and GHQ 4 (depression). 16632165 2006
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE However, for men, but not for women, we observed a strong and specific association between low neuroticism-anxiety and the A1+ allele of the DRD2 TaqI A polymorphism across two independent samples and across two alternative personality scales. 15812318 2005
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 GeneticVariation group BEFREE Within the bupropion group, subgroup analyses with stratification by genotype demonstrated that craving, irritability, and anxiety were significantly attenuated only among subjects with DRD2-Taq1 A2/A2 genotypes. 14668077 2003
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Earlier findings concerning association of DRD2 E8 A/A with increased anxiety and depression are replicated for the first time. 11692072 2001