|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is hypothesized that dopaminergic genes-dopamine type-2 receptor (DRD2), aldehyde dehydrogenase 2 (ALDH2), and catechol-O-methyltransferase (COMT)-are associated with bipolar disorder (BP) and anxiety disorder (AD).
|
25430946 |
2015 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder.
|
24229495 |
2014 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder.
|
24229495 |
2014 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese.
|
23044341 |
2013 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese.
|
23044341 |
2013 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain-derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder.
|
22514151 |
2012 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder.
|
22326841 |
2012 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
our data suggest: (i) C14ORF28, GNB2L1, MLLT3, DRD2 and DARPP-32 are important in the pathogenesis of schizophrenia and bipolar disorder; (ii) these two disorders share common disease-related mechanisms linked to dopamine signalling; (iii) the expression of these genes is closely correlated; and (iv) DRD2 provides the initial trigger in the pathogenesis of these disorders.
|
20874815 |
2011 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.
|
21292452 |
2011 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders.
|
18922583 |
2008 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One hundred twenty-four depressed inpatients affected by bipolar disorder (DSM-IV) were treated with TSD and were genotyped for DRD3 first exon Gly/Ser variants and DRD2 codon 311 Ser/Cys variants using polymerase chain reaction techniques.
|
12834818 |
2003 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the DRD2 microsatellite may be in linkage disequilibrium with a nearby genetic variant involved in the susceptibility to BPAD.
|
11857579 |
2002 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia.
|
10490710 |
1999 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Insertion/deletion variant (-141C Ins/Del) in the 5' regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder. Short communication.
|
9588764 |
1998 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association study of a functional variant in the promoter region of the dopamine D2 receptor (DRD2) with bipolar affective disorder I or unipolar major affective disorders was performed.
|
9754623 |
1998 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes.
|
8950413 |
1996 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.
|
7760324 |
1995 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 11q21-22 region, including DRD2, was surveyed by linkage analysis in a sample (N = 242) made of four large multigenerational pedigrees densely affected by schizophrenia (SZ) and eight others by bipolar disorder (BP).
|
8825888 |
1995 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of bipolar disorder using a functional polymorphism (Ser311-->Cys) in the dopamine D2 receptor gene.
|
7551964 |
1995 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The negative results obtained under different genetic models exclude a frequent role for DRD4, TH, TYR, and DRD2 in the pathogenesis of bipolar illness.
|
7903509 |
1994 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other promising results concern the tyrosine hydroxylase gene in manic depressive illness and the dopamine D2 receptor in alcoholism.
|
7919920 |
1994 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Exclusion of linkage between manic depressive illness and tyrosine hydroxylase and dopamine D2 receptor genes.
|
7914141 |
1994 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Linkage of bipolar disorder and recurrent depression to DRD1 and DRD2 was tested using a series of genetic models with varying penetrance levels.
|
1385598 |
1992 |