Cocaine Abuse
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
One functional single nucleotide polymorphism in dopamine receptor D2 (DRD2), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre- and postsynaptically. rs1076560 has been previously associated with cocaine abuse and we set out to confirm this association in a sample of European American (EA) (n = 336) and African American (AA) (n = 1034) cocaine addicts and EA (n = 656) and AA (n = 668) controls.
|
24359476 |
2014 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
PSYGENET |
One functional single nucleotide polymorphism in dopamine receptor D2 (DRD2), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre- and postsynaptically. rs1076560 has been previously associated with cocaine abuse and we set out to confirm this association in a sample of European American (EA) (n = 336) and African American (AA) (n = 1034) cocaine addicts and EA (n = 656) and AA (n = 668) controls.
|
24359476 |
2014 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
PSYGENET |
Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction.
|
23340505 |
2013 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
BEFREE |
ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse.
|
23635803 |
2013 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
PSYGENET |
ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse.
|
23635803 |
2013 |
Cocaine Abuse
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction.
|
23340505 |
2013 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
PSYGENET |
To assess the role of DRD2 variants in cocaine abuse, we measured levels of D2S and D2L mRNA in human brain autopsy tissues (prefrontal cortex and putamen) obtained from cocaine abusers and controls, and genotyped a panel of DRD2 SNPs (119 abusers and 95 controls).
|
21150907 |
2011 |
Cocaine Abuse
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
To assess the role of DRD2 variants in cocaine abuse, we measured levels of D2S and D2L mRNA in human brain autopsy tissues (prefrontal cortex and putamen) obtained from cocaine abusers and controls, and genotyped a panel of DRD2 SNPs (119 abusers and 95 controls).
|
21150907 |
2011 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys.
|
20494958 |
2010 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys.
|
20494958 |
2010 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats.
|
18418874 |
2008 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats.
|
18418874 |
2008 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration.
|
16541082 |
2007 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.
|
17332411 |
2007 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration.
|
16541082 |
2007 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.
|
17332411 |
2007 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving.
|
16971900 |
2006 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving.
|
16971900 |
2006 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior.
|
15010698 |
2004 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats.
|
15042275 |
2004 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats.
|
15042275 |
2004 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior.
|
15010698 |
2004 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists.
|
11923462 |
2002 |
Cocaine Abuse
|
0.540 |
Therapeutic
|
disease |
CTD_human |
Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization.
|
11751029 |
2002 |
Cocaine Abuse
|
0.540 |
Biomarker
|
disease |
CTD_human |
Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists.
|
11923462 |
2002 |