DRD2, dopamine receptor D2, 1813

N. diseases: 437; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression. 27472173 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (ηp(2)=.065) and depression (ηp(2)=.059), and for DRD2 rs2283265, depression (ηp(2)=.053). 24780147 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (ηp(2)=.065) and depression (ηp(2)=.059), and for DRD2 rs2283265, depression (ηp(2)=.053). 24780147 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D(2/3) receptor binding in healthy individuals (Con) as well as depression and addiction. 23683269 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D(2/3) receptor binding in healthy individuals (Con) as well as depression and addiction. 23683269 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Molecular genetic studies point to potential risk loci of psychotic depression shared with schizoaffective disorder (1q42, 22q11, 19p13), depression, bipolar disorder, and schizophrenia (6p, 8p22, 10p13-12, 10p14, 13q13-14, 13q32, 18p, 22q11-13) and several vulnerability genes possibly contributing to an increased risk of psychotic symptoms in depression (eg, BDNF, DBH, DTNBP1, DRD2, DRD4, GSK-3beta, MAO-A). 23512949 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease RGD Importantly, Par-4 and DRD2 mRNA levels significantly correlated with depression-like behaviors. 21596067 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy. 21540761 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Research implicates the A1 allele of the dopamine D2 receptor gene (DRD2) Taq1A polymorphism in the development of depression and anxiety. 20526230 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Research implicates the A1 allele of the dopamine D2 receptor gene (DRD2) Taq1A polymorphism in the development of depression and anxiety. 20526230 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The present study builds off this literature and examines whether DRD2 moderates the effect of violent victimization on depression. 18501970 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE It was found that the combination of COMT Met allele and DRD2 T allele predicted more severe depression in those already affected but did not predict the risk of depression when compared to normal population. 18929622 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE A number of studies suggest that variants in dopamine receptor genes, such as DRD2, are associated with depression but it is unclear if such variants also modify the association between life events and depression. 17585060 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Subjects with the DRD2 Al allele compared to those without this allele had significantly higher scores on GHQ 2 (anxiety/insomnia), GHQ 3 (social dysfunction) and GHQ 4 (depression). 16632165 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Individuals high in trait depression or nicotine dependence or with at least one dopamine D(2) receptor A1 allele experienced greater EEG deactivation following abstinence, especially in the right hemisphere during the stressful task. 15203798 2004
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Before paroxetine treatment, patients with the DRD2 A1+ allele (A1A2 genotype) compared to those with the A1- allele (A2A2 genotype) had higher total GHQ psychopathological scores (P=0.040) and higher GHQ subscale scores for anxiety/insomnia (0.046), social dysfunction (P=0.033) and depression (P=0.011). 12957328 2003
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Earlier findings concerning association of DRD2 E8 A/A with increased anxiety and depression are replicated for the first time. 11692072 2001