|
Drug abuse
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Similarly, women with a BSD who reported a history of childhood sexual abuse showed a trend-level elevation of DRD2 methylation compared to our NED group.
|
24157248 |
2014 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We hypothesize that dopamine D2 receptor (DRD2) gene Taq1 A2 allele is associated with a subtype of non-SUD schizophrenics and as such may act as a putative protective agent against the development of addiction to alcohol or other drugs of abuse.
|
24636783 |
2014 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
Dopamine (DA) neurotransmission through D2 receptors (DRD2) has been implicated in the regulation of reward processing, cognition and the effects of drugs of abuse, and also has significant effects in responses to stressors and salient aversive stimuli.
|
22424959 |
2013 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sensation Seeking was elevated in carriers of the low-function allele of the DRD2 Taq1A polymorphism who also reported childhood sexual abuse, relative to that in individuals showing other combinations of alleles and abuse exposures.
|
22733030 |
2012 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The DRD2 Taq1 A1 allele was present in 67% of the O/OW subjects compared to 3.3% of super controls (A group), 33.3% of screened (for drug abuse and obesity) controls (B group) and unscreened literature controls 29.4% (P≤ 0.001).
|
22051885 |
2012 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
With severity of abuse accounted for in the model, genetic effects of the DRD2 and DRD4 polymorphisms were still significant (DRD2 TaqIB: p = 0.001, DRD2 TaqIA: p = 0.008, DRD4 -616 C/G: p = 0.002).
|
20205808 |
2010 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The DRD2 genotype may pose an increased risk for alcohol use and abuse, depending on the presence of environmental risk factors, such as alcohol-specific parenting.
|
19238152 |
2010 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
CTD_human |
Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward.
|
16901644 |
2006 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
Increases in dopamine D(2) receptor sensitivity are known to be common in drug abuse and neurological disorders.
|
15066159 |
2004 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Studies in the past decade have shown that in various subject groups the Taq I A1 allele of the DRD2 gene is associated with alcoholism, drug abuse, smoking, obesity, compulsive gambling, and several personality traits.
|
11105655 |
2000 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The frequency of the TaqI A(1) allele of the D(2) dopamine receptor (DRD2) gene was 19.0% in these patients compared with 4.6% in controls free of past and current alcohol and other drug abuse and free of family history of alcohol and other drug abuse (p = 0.009).
|
11054765 |
2000 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
The relationship of various dimensions of temperament, measured by the Tridimensional Personality Questionnaire (TPQ), to polymorphisms of the D2 dopamine receptor (DRD2) and D4 dopamine receptor (DRD4) genes was determined in 119 healthy Caucasian boys who had not yet begun to consume alcohol and other drugs of abuse.
|
9603615 |
1998 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data are consistent with the hypothesis that DRD2 gene variants marked by these polymorphisms may work, probably in concert with other genetic and environmental factors, to enhance vulnerability to psychostimulant abuse.
|
8894071 |
1996 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The dopamine D2 receptor gene (DRD2) appears to be one of these genes since variants at this locus are significantly increased in frequency in TS, ADHD, conduct disorder and drug abuse.
|
8082550 |
1994 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Similarly, subjects who abuse illegal drugs or who are obese also show a significantly higher prevalence of the A1 DRD2 allele compared to controls.
|
8072432 |
1994 |
|
Drug abuse
|
0.400 |
Biomarker
|
group |
BEFREE |
To examine the possible role of genetic variants of the dopamine D2 (DRD2) gene in susceptibility to drug abuse we determined the prevalence of the TaqI A1 variant of the DRD2 gene in 200 white patients hospitalized in the Addiction Treatment Unit of a Veterans Administration Hospital.
|
8033754 |
1994 |
|
Drug abuse
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Dopamine D2 receptor gene Taq I 'A' locus map including 'A4' variant: relevance for alcoholism and drug abuse.
|
8096458 |
1993 |