|
Heroin Dependence
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This enhancer variant had been shown to increase DRD2 mRNA expression, a possible factor in increased vulnerability to heroin addiction.
|
31025317 |
2019 |
|
Heroin Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
According to the allele, genotype and haplotype frequency analysis, we observed an association between HD and several DRD2/ANKK1 polymorphisms (rs1800497, rs1800498, rs1079597 and rs4648319); this was most notable in the late-onset HD subgroup.
|
28854834 |
2019 |
|
Heroin Dependence
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notably, a 35.8 kilobases (kb) haplotype spanning ANKK1 and DRD2 was found to be a strong protective factor for heroin dependence.
|
29550268 |
2018 |
|
Heroin Dependence
|
0.600 |
Biomarker
|
disease |
BEFREE |
Reward- and memory-related candidate genes dopamine D2 receptor (DRD2) and brain-derived neurotrophic factor (BDNF), as well as the opioid receptor genes (OPRM1, OPRD1, and OPRK1), have been implicated in drug dependence, but relatively little is known on their contributions to heroin dependence in populations worldwide.
|
28692418 |
2017 |
|
Heroin Dependence
|
0.600 |
Biomarker
|
disease |
RGD |
Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression.
|
28598964 |
2017 |
|
Heroin Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings point to a role for DRD2 polymorphism in heroin dependence in the Chinese Han population, and may be informative for future genetic or neurobiological studies on heroin dependence.
|
27819741 |
2016 |
|
Heroin Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ALDH2*1/*1, ADH1B*1/*1, and ADH1B*1/*2 genotypes may interact and protect their carriers against heroin dependence and the protective effect may be varied by the DRD2 gene polymorphism.
|
23266708 |
2013 |
|
Heroin Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To study the potential association between allelic variants of dopamine D2 receptor (DRD2), ANKK1 (ankyrin repeat and kinase domain containing 1), dopamine D4 receptor (DRD4), catechol-O-methyl transferase (COMT) and dopamine transporter (SLC6A3) genes and heroin dependence in Hungarian patients.
|
23840506 |
2013 |
|
Heroin Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ALDH2 polymorphism, but not the DRD2, was associated with heroin dependence.
|
21723677 |
2012 |
|
Heroin Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Potential association of DRD2 and DAT1 genetic variation with heroin dependence.
|
19664686 |
2009 |
|
Heroin Dependence
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Using data from a study of association between heroin dependence and the DRD2 gene, we obtained estimated haplotype frequencies and the associated likelihood ratio statistic using two different computer programs, MLOCUS and GENECOUNTING.
|
17597526 |
2007 |
|
Heroin Dependence
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results strongly support a role of DRD2 as a susceptibility gene with heroin dependence in Chinese patients and was associated with low risk of heroin dependence in Germans.
|
15184239 |
2004 |
|
Heroin Dependence
|
0.600 |
Biomarker
|
disease |
CTD_human |
Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization.
|
11751029 |
2002 |