Cocaine Dependence
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In this same group, interaction analysis demonstrated that the presence of DRD2-T allele and concomitant absence of DRD4-7R allele were associated with risk for crack cocaine addiction.
|
30367264 |
2019 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
RGD |
High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens.
|
29454035 |
2018 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
BEFREE |
These heteroreceptor complexes can potentially be targeted for future pharmacotherapy of cocaine addiction by using heterobivalent compounds or A2AR-D2R receptor interface-interfering peptides that disrupt the A2AR-D2R-Sigma1R complexes.
|
30384981 |
2018 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
PSYGENET |
We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P < 0.05) in Caucasian subjects, but not African-American individuals.
|
24078558 |
2013 |
Cocaine Dependence
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram.
|
23635803 |
2013 |
Cocaine Dependence
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P < 0.05) in Caucasian subjects, but not African-American individuals.
|
24078558 |
2013 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram.
|
23635803 |
2013 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
BEFREE |
Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability.
|
22832851 |
2012 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability.
|
22832851 |
2012 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
PSYGENET |
We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls.
|
20505554 |
2010 |
Cocaine Dependence
|
0.800 |
Therapeutic
|
disease |
CTD_human |
Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys.
|
20494958 |
2010 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
CTD_human |
Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys.
|
20494958 |
2010 |
Cocaine Dependence
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls.
|
20505554 |
2010 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results.
|
20801583 |
2010 |
Cocaine Dependence
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD.
|
20170711 |
2010 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
BEFREE |
Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results.
|
20801583 |
2010 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
CTD_human |
D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats.
|
18418874 |
2008 |
Cocaine Dependence
|
0.800 |
Therapeutic
|
disease |
CTD_human |
D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats.
|
18418874 |
2008 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
CTD_human |
Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration.
|
16541082 |
2007 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
CTD_human |
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.
|
17332411 |
2007 |
Cocaine Dependence
|
0.800 |
Therapeutic
|
disease |
CTD_human |
Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration.
|
16541082 |
2007 |
Cocaine Dependence
|
0.800 |
Therapeutic
|
disease |
CTD_human |
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.
|
17332411 |
2007 |
Cocaine Dependence
|
0.800 |
Therapeutic
|
disease |
CTD_human |
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving.
|
16971900 |
2006 |
Cocaine Dependence
|
0.800 |
Biomarker
|
disease |
CTD_human |
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving.
|
16971900 |
2006 |
Cocaine Dependence
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our data do not support a role for the dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample.
|
16094250 |
2005 |