DRD3, dopamine receptor D3, 1814

N. diseases: 199; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 GeneticVariation disease BEFREE The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson's Disease. 31143436 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease BEFREE The aim of the present study was to examine the role of DRD3 in the anxiety-like and depression-like behavioral changes induced by estrogen and progesterone. 30292827 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease BEFREE The altered expression and function of dopamine receptor D3 (D3R) in patients and animal models have been correlated with depression disease severity. 29390063 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease PSYGENET The aim of the present study was to examine the role of dopamine D3 receptor on the anxiety-like and depression-like behaviors induced by immobilization stress. 23357086 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 GeneticVariation disease BEFREE Direct associations were identified between the dopamine receptor 3 (DRD3) BalI polymorphism and depression; the dopamine receptor 1 (DRD1) and dopamine transporter gene 3' VNTR polymorphisms and aberrant motor behavior; the DRD4 VNTR and sleep disturbances; and the SERT gene VNTR 5HTTLPR and apathy items. 20685009 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease PSYGENET Direct associations were identified between the dopamine receptor 3 (DRD3) BalI polymorphism and depression; the dopamine receptor 1 (DRD1) and dopamine transporter gene 3' VNTR polymorphisms and aberrant motor behavior; the DRD4 VNTR and sleep disturbances; and the SERT gene VNTR 5HTTLPR and apathy items. 20685009 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease PSYGENET Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). 21630437 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease BEFREE Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). 21630437 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease PSYGENET Associations were revealed between DRD3 and elation, and between DRD4 with agitation/aggression and with depression; however, these findings do not remain significant after correction for multiple testing. 19235789 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease BEFREE Associations were revealed between DRD3 and elation, and between DRD4 with agitation/aggression and with depression; however, these findings do not remain significant after correction for multiple testing. 19235789 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 Biomarker disease PSYGENET Depression and psychotic symptoms that occur in a large proportion of AD patients have been associated with monoamine genes coding for metabolic enzymes (COMT), transporters (5-HTTLPR) and receptors (DRD1; DRD3). 17851196 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.370 GeneticVariation disease BEFREE Depression and psychotic symptoms that occur in a large proportion of AD patients have been associated with monoamine genes coding for metabolic enzymes (COMT), transporters (5-HTTLPR) and receptors (DRD1; DRD3). 17851196 2007