|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al.
|
31773210 |
2020 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings may help to improve the understanding of the relationship between 5-HT2A and DRD3 genotypes and schizophrenia pathogenesis.
|
31813806 |
2019 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated 15 single-nucleotide polymorphisms (SNPs) in DRD3 and four SNPs in BDNF for possible association with alcohol abuse or dependence in schizophrenia patients of European ancestry (N = 195).
|
29357295 |
2018 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
In combination with previous studies, these results suggest that cariprazine has a unique pharmacological profile and distinct dopamine D3 receptor-dependent mechanism of action that may be beneficial in the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
|
28531264 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association between dopamine D3 receptor gene rs6280" genes_norm="1814">Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis.
|
29200860 |
2017 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We previously reported that YQA31 is a dopamine D3 receptor antagonist with modest 5-HT1A receptor affinity and that it exhibits antipsychotic properties in animal models of schizophrenia.
|
29128790 |
2017 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Expression of the dopamine D3 (DRD3) receptor was significantly increased in clozapine-treated schizophrenia and covaried significantly with differentiated T cell classes in the CD4+ lineage.
|
27244229 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To assess the relationship between cognitive function, a proposed schizophrenia endophenotype, and two genetic polymorphisms related to dopamine function, catechol-O-methyl transferase (COMT) Val158Met and dopamine receptor 3 (DRD3) Ser9Gly.
|
26376054 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results indicated that DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.
|
27591410 |
2016 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrated that the mRNA expression levels of DRD3 in T lymphocytes were significantly different among controls, and in patients with psychotic disorder not otherwise specified (NOS) and schizophrenia/schizophreniform disorder.
|
26561806 |
2015 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together, the results from the present study suggest that an interaction between BDNF and DRD3 may not play a major role in the risk for suicide attempt, though further studies, especially in SCZ, are required.
|
25264289 |
2015 |
|
Schizophrenia
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Significant association between DRD3 gene body methylation and schizophrenia.
|
25262640 |
2014 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Antipsychotic haloperidol binding to the human dopamine D3 receptor: beyond docking through QM/MM refinement toward the design of improved schizophrenia medicines.
|
25181639 |
2014 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The dopamine D3 receptor (DRD3) gene has been implicated in schizophrenia, autism, and substance use-disorders and is related to emotion reactivity, executive functioning, and stress-responding, processes impaired in posttraumatic stress disorder (PTSD).
|
25158632 |
2014 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Eight SNPs were nominally associated with SZ in either case-control or family based analyses (p < 0.05, rs7631540 and rs2046496 in DRD3; rs363399 and rs10082463 in SLC18A2; rs4680, rs4646315 and rs9332377 in COMT). rs6271 at DBH was associated in both analyses.
|
23932573 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152).
|
22940547 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A DRD3 gene polymorphism results in an S9G amino-acid change that has been associated with lower risk of schizophrenia, higher affinity for dopamine and some antipsychotics, and differential response to some antipsychotics.
|
23571810 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In our Japanese case-control sample (43 with TD/157 without TD), we found no association between the DRD3 Ser9Gly polymorphism in schizophrenia and TD (genotype: p=0.92; allele: p=1.00).
|
22172931 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To identify whether functional variants of the D2-like receptors (DRD2, DRD3 and DRD4) confer risk of schizophrenia, we conducted a two-stage association study.
|
22569179 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A synergic effect of DRD3 polymorphisms on schizophrenia susceptibility is suggested.
|
21737144 |
2011 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Overexpression of HERV-w env in human U251 glioma cells upregulated brain-derived neurotrophic factor (BDNF), an important schizophrenia-associated gene, neurotrophic tyrosine kinase receptor type 2 (NTRK2, also called TrkB), and dopamine receptor D3 and increased the phosphorylation of cyclic adenosine monophosphate response element-binding (CREB) protein.
|
20100784 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of (1) these known associations with DRD3, (2) the recent finding of Costas and colleagues that a haplotype containing Ser-9 is associated with protection from schizophrenia, and (3) an extant trait model of personality, leads to the hypothesis that an allele DRD3/Ser codes for trait aggression by Mendelian recessive inheritance.
|
21963356 |
2011 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We concluded that the levels of DRD3 mRNA can help understanding and severity of clinical manifestations in schizophrenia.
|
21110120 |
2011 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
To explore the potential role of DRD3 in SZ from these various aspects, we conducted a threefold study.
|
21595009 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Based on allele and genotype frequencies in both groups, we found no significant association of DRD3 Ser9Gly polymorphisms and COMT (rs165656) with schizophrenia in Malays.
|
21948748 |
2011 |