|
Essential Tremor
|
0.300 |
Therapeutic
|
disease |
RGD |
Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.
|
26459182 |
2016 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We analyzed in ET Spanish families three single nucleotide polymorphisms (SNPs): DRD3 rs6280, SLC1A2 rs3794087, and MAPT rs1052553) previously related to an increased risk for developing the disease.
|
27456607 |
2016 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present meta-analysis does not support the notion that the DRD3 Ser9Gly variant is a genetic risk factor for ET.
|
24054403 |
2013 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recently, in a large ET family (FET1) from Quebec, a non-sense mutation (p.Q290X) in the amyotrophic lateral sclerosis (ALS) gene fused in sarcoma/translated in liposarcoma (FUS/TLS) was identified by exome sequencing.
|
23114103 |
2013 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recently, an association between the dopamine D(3) receptor (DRD3) Ser9Gly polymorphism and ET has been reported.
|
20434388 |
2010 |
|
Essential Tremor
|
0.300 |
Biomarker
|
disease |
BEFREE |
Variants in the dopamine receptor D3 (DRD3) and HCLS1 binding protein 3 (HS1BP3) have been nominated as risk factors for essential tremor (ET).
|
19524641 |
2009 |
|
Essential Tremor
|
0.300 |
Biomarker
|
disease |
BEFREE |
We did not find a significant association of the DRD3 variant with ET nor linkage to the DRD3 receptor in German, Danish and French ET patients and families, suggesting that it is unlikely to be a causal factor for ET.
|
19092771 |
2009 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that DRD3 genotype and the variant DRD3Gly allelic variant is associated with the risk for and age at onset of ET, and with the risk for voice tremor, in Caucasian Spanish people.
|
19645064 |
2009 |
|
Essential Tremor
|
0.300 |
Biomarker
|
disease |
BEFREE |
To date, linkage analyses revealed three loci associated to essential tremor (ET) (ETM1 on 3q13, ETM2 on 2p22-25, and a locus on 6p23).
|
17703985 |
2008 |
|
Essential Tremor
|
0.300 |
Biomarker
|
disease |
LHGDN |
Reappraisal of the role of the DRD3 gene in essential tremor.
|
18316228 |
2008 |
|
Essential Tremor
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our comprehensive genetic analysis in a large ET cohort strongly argues against the role of the DRD3 gene in ET pathogenesis.
|
18316228 |
2008 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
DRD3 Ser9Gly variant is not associated with essential tremor in a series of Italian patients.
|
18484990 |
2008 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results do not support an association between DRD3 Ser9Gly and susceptibility to ET in Italian patients.
|
18484990 |
2008 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor.
|
16809426 |
2006 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Two genetic loci have been identified in autosomal dominant (AD) ET and polymorphisms in the DRD3 and HS1-BP3 genes have been proposed as the possible susceptibility factors for ET.
|
16721753 |
2006 |
|
Essential Tremor
|
0.300 |
Biomarker
|
disease |
BEFREE |
The gain-of-function produced by the Gly-9 variant may explain why drugs active against tremor in Parkinson's disease (PD) are usually not effective in the treatment of ET and suggests that DRD3 partial agonists or antagonists should be considered as novel therapeutic options for patients with ET.
|
16809426 |
2006 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage studies have identified two susceptibility loci for essential tremor (ET) on chromosomes 3q13 (ETM1) and 2p24.1 (ETM2).
|
15699368 |
2005 |
|
Essential Tremor
|
0.300 |
Biomarker
|
disease |
BEFREE |
The examined loci were PARK3, Parkin, DRD (dopa-responsive dystonia), FET1 (familial essential tremor), BDNF (brain-derived neurotrophic factor), GDNF (glial cell line-derived neurotrophic factor), Ret, DAT1 (the dopamine transporter), Nurr1 and Synphilin-1.
|
12882651 |
2003 |
|
Essential Tremor
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We now report evidence for linkage to the ETM locus in three additional, unrelated American families with ET and exclude the FET1 locus in these families.
|
9827627 |
1998 |