DRD3, dopamine receptor D3, 1814

N. diseases: 199; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Therapeutic disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease CTD_human The dopamine D3/D2 agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] protects against acute and cocaine-kindled seizures in mice: further evidence for the involvement of D3 receptors. 18566292 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Therapeutic disease CTD_human The dopamine D3/D2 agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] protects against acute and cocaine-kindled seizures in mice: further evidence for the involvement of D3 receptors. 18566292 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Therapeutic disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 GeneticVariation disease BEFREE Our data do not support a role for the dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample. 16094250 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease PSYGENET Our data do not support a role for the dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample. 16094250 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Therapeutic disease CTD_human Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior. 15100700 2004
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease CTD_human Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior. 15100700 2004
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease PSYGENET BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. 12847556 2003
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease PSYGENET These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Therapeutic disease CTD_human These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease BEFREE These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker disease CTD_human These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999