DRD3, dopamine receptor D3, 1814

N. diseases: 199; N. variants: 13
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease BEFREE In combination with previous studies, these results suggest that cariprazine has a unique pharmacological profile and distinct dopamine D3 receptor-dependent mechanism of action that may be beneficial in the treatment of schizophrenia, bipolar disorder, and major depressive disorder. 28531264 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease BEFREE Rs2399496, located 1.5 kb downstream of DRD3, showed suggestive association for MDD (p = 0.00076) and significant association for MDD-ND co-morbidity (p = 0.000079). 24927283 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease PSYGENET Rs2399496, located 1.5 kb downstream of DRD3, showed suggestive association for MDD (p = 0.00076) and significant association for MDD-ND co-morbidity (p = 0.000079). 24927283 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease PSYGENET Altogether, 10 representative variants covering 95.4% of DRD3 gene variation were investigated for association with response to ECT in a sample of 104 (71 female, 33 male) Caucasian patients with pharmacorefractory major depression. 22093107 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 GeneticVariation disease BEFREE Altogether, 10 representative variants covering 95.4% of DRD3 gene variation were investigated for association with response to ECT in a sample of 104 (71 female, 33 male) Caucasian patients with pharmacorefractory major depression. 22093107 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease PSYGENET In a sample of 308 Chinese Han patients with major depressive disorder, 13 single nucleotide polymorphisms (SNPs) in coding regions of six genes (MAOA, SLC6A2, TH, COMT, DRD2, DRD3) with minor allele frequencies >5% were successfully genotyped from an initial series of 35 SNPs in 11 candidate genes associated with catecholamine neurotransmission. 21680027 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease PSYGENET A follow-up case-control association study of tractable (druggable) genes in recurrent major depression. 21630437 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 GeneticVariation disease BEFREE Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression. 16583407 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease PSYGENET Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression. 16583407 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease BEFREE The possible involvement of dopamine receptor D3 in unipolar (UP) major depression was investigated by a genetic association study of the D3 receptor gene locus (DRD3) on 36 UP patients and 38 ethnically matched controls. 10697826 1999
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 GeneticVariation disease BEFREE Pairwise linkage analyses were carried out between the D3 dopamine receptor gene locus (DRD3) and schizophrenia (including major depression among its pleiotropic manifestations). 8464957 1993