|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The inconsistent findings on the prediction of disorganized attachment from the dopamine D4 receptor (DRD4) gene, birth weight, and maternal depression as well as the evidence supporting the contribution of early maternal care, suggest the importance of exploring a gene by environment model.
|
29149620 |
2018 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months.
|
27427178 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We replicated previous findings of association of infant DRD4 x maternal sensitivity interactions with child Externalizing problems in the European-ancestry sample (N = 42) in a median split of maternal sensitivity (p = .00011, eta2 = .329) and in regression analyses controlling for maternal age, maternal depression, and child gender in European ancestry (B = -3.4, SE 1.33, p = .01) and the total sample (B = -2.2, SE 1.02, p = .02).
|
27494520 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Genotypes for the COMT Val158Met and DRD4 VNTR-48 polymorphisms and TCI Harm Avoidance and MMPI Depression scales' scores were obtained as well.
|
25011686 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Molecular genetic studies point to potential risk loci of psychotic depression shared with schizoaffective disorder (1q42, 22q11, 19p13), depression, bipolar disorder, and schizophrenia (6p, 8p22, 10p13-12, 10p14, 13q13-14, 13q32, 18p, 22q11-13) and several vulnerability genes possibly contributing to an increased risk of psychotic symptoms in depression (eg, BDNF, DBH, DTNBP1, DRD2, DRD4, GSK-3beta, MAO-A).
|
23512949 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Gene × environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children.
|
23627963 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study examined associations between the DRD4 gene 48bp VNTR polymorphism and comorbidity between marijuana use frequency and depression in a diverse, non-clinical adolescent sample (n=1882; ages 14 to 18) from the National Longitudinal Study of Adolescent Health (Add Health).
|
23796967 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
No research has examined whether DRD4 variation is associated with biased attention for contextually cued emotion stimuli, an important putative intermediate phenotype for a number of pathologies (e.g. depression and anxiety).
|
22607734 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
This study examined associations between the DRD4 gene 48bp VNTR polymorphism and comorbidity between marijuana use frequency and depression in a diverse, non-clinical adolescent sample (n=1882; ages 14 to 18) from the National Longitudinal Study of Adolescent Health (Add Health).
|
23796967 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No research has examined whether DRD4 variation is associated with biased attention for contextually cued emotion stimuli, an important putative intermediate phenotype for a number of pathologies (e.g. depression and anxiety).
|
22607734 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Direct associations were identified between the dopamine receptor 3 (DRD3) BalI polymorphism and depression; the dopamine receptor 1 (DRD1) and dopamine transporter gene 3' VNTR polymorphisms and aberrant motor behavior; the DRD4 VNTR and sleep disturbances; and the SERT gene VNTR 5HTTLPR and apathy items.
|
20685009 |
2012 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the current study we tested whether the dopamine receptor D4 (DRD4) genotype moderates the association of experienced parental problems during childhood (e.g., parental depression, marital discord) with unresolved loss or trauma during the Adult Attachment Interview.
|
21506030 |
2011 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data, in combination with a review of the literature, reveal a potential role for the VNTR variant of DRD4 in the development of depression in AD patients.
|
19235789 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Relative to the other more common DRD4 variants, the DRD4*379/379 genotype raises the level of depression by about 0.25 points (about 17% of the mean).
|
19125104 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This trend was also observed in the two other studies that contained unrelated subjects diagnosed with depression (N = 143 and N = 148) but the associations between DRD4 duplication genotype and NS were not significant in these groups.
|
15048656 |
2004 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the suicide-related measures demonstrated a significant difference in depression severity between suicidal inpatients homozygote and heterozygote for the DRD4 alleles (p=0.003).
|
15565493 |
2004 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant interaction (DRD4 Genotype x Depression) was found for stimulation smoking and negative-affect reduction smoking.
|
9459071 |
1998 |