DRD4, dopamine receptor D4, 1815

N. diseases: 189; N. variants: 7
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Polymorphisms of the DRD4 gene appear to be associated with SSRI treatment response in Chinese MDD patients. 25854875 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression. 26974654 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Polymorphisms of the DRD4 gene were associated with SSRI response in Chinese Han MDD patients. 25642918 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Two notable exceptions are the DRD4 and DAT gene: both have variable tandem repeat polymorphisms which may have a "single gene" influence on susceptibility to MDD. 20558238 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET Two notable exceptions are the DRD4 and DAT gene: both have variable tandem repeat polymorphisms which may have a "single gene" influence on susceptibility to MDD. 20558238 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET To date, there is statistically significant evidence for six MDD susceptibility genes (APOE, DRD4, GNB3, MTHFR, SLC6A3 and SLC6A4). 17938638 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. 16756688 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET Patients with mood disorders (N = 125: bipolar subtype, n = 100; major depressive disorder subtype, n = 25) were followed prospectively for an average of 53 months and were typed for DRD2 (Ser311/Cys311: n = 121, VNTR: n = 63), DRD4 (n = 125) and GABRA1 (n = 61) variants using polymerase chain reaction (PCR) techniques. 10512150 1999
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET In the present study, 102 unipolar MDD patients and 172 healthy controls were genotyped for polymorphisms in four serotonergic and three dopaminergic candidate genes [tryptophan hydroxylase (TPH), serotonin receptor 2A (HTR2A), serotonin receptor 2C (HTR2C), serotonin transporter promoter region (5-HTTLPR), dopamine receptor D4 (DRD4), dopamine transporter (DAT1) and catechol-O-methyl transferase (COMT)]. 10483058 1999