Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined bidirectional relations between attention-deficit/hyperactivity disorder (ADHD) symptoms and family and school climate, and the possible role of DRD4 and/or 5-HTTLPR genotypes herein.
|
31628528 |
2019 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusions:</b> Prefrontal gyrification is reduced in children with ADHD who also carry the DRD4 7R allele, and it relates to critical functional skills in the executive domain in carriers of the risk allele.
|
31105599 |
2019 |
Attention Deficit Disorder
|
0.500 |
Biomarker
|
disease |
CTD_human |
The interactions among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of dopamine receptor D4 increase the risk of attention deficit/hyperactivity disorder in children.
|
29054088 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The present findings indicate that the interaction between methylation of CpG7 of DRD4 and prenatal maternal stress may be predictive of the treatment response to MPH in youth with ADHD.
|
29905488 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to investigate the effects of regulation of the dopamine D4 receptor (DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity (ReHo) and functional connectivity (FC).
|
29564731 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An association between the presence of the long allele of the DRD4 gene polymorphism and ADHD-like failure in CPT performance was evident in the non-affected parents of adolescents with ADHD in childhood.
|
30338900 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study provided novel insights into the neural mechanisms underlying the effects of DRD4 2-repeat allele on ADHD.
|
30050420 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The effects of GRIN2B and DRD4 gene variants on local functional connectivity in attention-deficit/hyperactivity disorder.
|
28258362 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After adjustment for other covariates, children who carried the DRD4 GG genotype, had been exposed to high DMP levels (more than the median), and had high HNE-MA levels had a significantly increased risk for developing ADHD (OR = 11.74, 95% CI: 2.12-65.04).
|
29054088 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
CTD_human |
After adjustment for other covariates, children who carried the DRD4 GG genotype, had been exposed to high DMP levels (more than the median), and had high HNE-MA levels had a significantly increased risk for developing ADHD (OR = 11.74, 95% CI: 2.12-65.04).
|
29054088 |
2018 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This endorses the general thesis that DRD4 exon 3 VNTR polymorphism is related to ADHD, despite that the exact length or number of repeats of the associated alleles varies across ethnicity.
|
28282463 |
2017 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Dopamine D4 Receptor Gene Polymorphism in a Sample of Egyptian Children With Attention-Deficit Hyperactivity Disorder (ADHD).
|
27821512 |
2017 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Given that prenatal exposure to alcohol or smoking is known to affect dopamine-rich brain regions, we hypothesized that individuals carrying the ADHD risk alleles of the dopamine receptor D4 (<i>DRD4</i>) and dopamine transporter (<i>DAT1</i>) genes may be especially sensitive to their effects.
|
28234207 |
2017 |
Attention deficit hyperactivity disorder
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
To examine the association of the DNA methylation of DAT1 and DRD4 gene with methylphenidate (MPH) response in attention deficit hyperactivity disorder (ADHD).
|
27676100 |
2017 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Findings indicated that parental DRD4 variants moderated the impact of parental ADHD and neurocognitive functioning on youth ADHD symptoms.
|
28138806 |
2017 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a large observational ADHD cohort study (N = 316), the effects of cumulative stimulant treatment, genotype (for DAT1 haplotype and DRD4 variants), and treatment-by-genotype interactions on striatal, frontal, and hippocampal volumes and their interactions with age were evaluated.
|
27663943 |
2016 |
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
We tested associations between ADHD symptoms and epigenetic changes to the DRD4 gene in DNA extracted from blood and saliva in N = 330 children referred for a variety of behavioural and emotional problems.
|
26897359 |
2016 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Aberrant regulation of synchronous network activity by the attention-deficit/hyperactivity disorder-associated human dopamine D4 receptor variant D4.7 in the prefrontal cortex.
|
26541360 |
2016 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the dopamine D4 receptor (DRD4) have previously been shown to associate with a variety of human behavioral phenotypes, including ADHD pathology, alcohol and tobacco craving, financial risk-taking in males, and broader personality traits such as novelty seeking.
|
26581567 |
2016 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADHD-associated dopamine polymorphisms within the DRD4, DRD2, and DAT1 genes were genotyped.
|
25271118 |
2015 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The dopamine D4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit hyperactivity disorder.
|
26717573 |
2015 |
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic studies of ADHD mainly focused on the Dopamine Transporter (DAT1) and the Dopamine Receptor 4 (DRD4) genes.
|
25555995 |
2015 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also genotyped the exon 3 VNTR of DRD4, the 7-repeat allele of which is also an established risk factor for childhood ADHD.
|
25656223 |
2015 |
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD) and substantially exists in Asian populations, which have a lower ADHD prevalence.
|
25659462 |
2015 |
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Moreover, possessing greater genetic risk on three dopaminergic genes (DAT1, DRD2, and DRD4) relative to a sibling appears to exacerbate the link between sibling differences in birth weight and sibling differences in ADHD symptomatology.
|
25704081 |
2015 |