Hypertrophic Cardiomyopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The molecular variant of angiotensinogen T235 seems to be a predisposing factor for cardiac hypertrophy in HCM and carries an approximately twofold increased risk.
|
9023164 |
1997 |
Hypertrophic Cardiomyopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the role of 3 potential modifier genes, i.e., angiotensinogen (AGT), angiotensin II receptor 1a (AT1a), and endothelin-1 (END1) on the phenotypic expression of LVH in patients with hypertrophic cardiomyopathy (HCM).
|
9444881 |
1997 |
Hypertrophic Cardiomyopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The development of left ventricular hypertrophy (LVH) in subjects with hypertrophic cardiomyopathy (HCM) is variable, suggesting a role for modifying factors such as angiotensin II.
|
9822439 |
1998 |
Hypertrophic Cardiomyopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined whether the blockade of angiotensin II, a known cardiotrophic factor, could reverse or attenuate interstitial fibrosis in a transgenic mouse model of human HCM.
|
11171784 |
2001 |
Hypertrophic Cardiomyopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy.
|
11751703 |
2001 |
Hypertrophic Cardiomyopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin II type 1 receptor (AT-1) mediates the major pressor and trophic actions of angiotensin II (Ang II) and at least 50 different polymorphisms have been described in the AT-1 gene (AT(1)R gene); in particular, the C allele of the +1166A/C polymorphism has been associated with the severe form of essential hypertension, but the role of this polymorphism is still ambiguous in pathologies related to high Ang II levels, such as deterioration of renal function, arterial stiffness and hypertrophic cardiomyopathy.
|
15640279 |
2005 |
Hypertrophic Cardiomyopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results have shown potential beneficial effects of angiotensin II receptor blocker losartan, mineralocorticoid receptor blocker spironolactone, 3-hydroxy-3-methyglutaryl-coenzyme A reductase inhibitors simvastatin and atorvastatin, and most recently, N-acetylcysteine (NAC) on reversal or prevention of hypertrophy and fibrosis in HCM.
|
20560006 |
2009 |
Hypertrophic Cardiomyopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The M235T polymorphism of the angiotensinogen gene in South Indian patients of hypertrophic cardiomyopathy.
|
21163864 |
2011 |
Hypertrophic Cardiomyopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For the association of AGT M235T polymorphism and HCM, "angiotensin converting enzyme" or "ACE" was replaced with "angiotensinogen".
|
24204726 |
2013 |
Hypertrophic Cardiomyopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also, 235TT genotype of AGT (M235T) was significantly associated with enhanced risk of the disease phenotype in HCM, DCM, and RCM.
|
28120210 |
2017 |
Hypertrophic Cardiomyopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed significantly increased ADAM22 expression in failing hearts from patients with dilated cardiomyopathy and hypertrophic cardiomyopathy; the same trend was observed in mice induced by transaortic constriction and in neonatal rat cardiomyocytes treated by angiotensin II.
|
29358191 |
2018 |
Hypertrophic Cardiomyopathy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the effects of GDF11 on Angiotensin II (ANG II)-induced hypertrophic cardiomyopathy and expression of markers for volume overload and hypertrophy such as ANP, BNP and beta-MHC, as well as the relationship between GDF11 and CCL11 in hypertrophic cardiomyopathy are unclear.
|
30714521 |
2018 |