IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since angiotensin II is thought to play an important role in the evolution of renal disease in general, we tested whether genotype distribution of the I/D polymorphism is also different in patients with immunoglobulin A-glomerulonephritis (IgA-GN).
|
7485124 |
1995 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy.
|
9259580 |
1997 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy.
|
9259580 |
1997 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Deletion/insertion polymorphism (D/I) of the angiotensin I converting enzyme gene, M235T polymorphism (T/M) of the angiotensinogen gene and A1166C polymorphism (C/A) of the angiotensin II type 1 receptor gene were determined in 274 Caucasian men with biopsy-proven IgAN (n = 86, 112, and 76 in stages 1, 2, and 3, respectively).
|
11053482 |
2000 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the TT genotype of the AGT gene and the ID/DD genotype of the ACE gene are associated with increased severity of proteinuria, suggesting that AGT and ACE gene polymorphisms may play a significant role in the progression of IgA nephropathy in Japanese children.
|
11354780 |
2001 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A(-20)C polymorphism of the angiotensinogen gene and progression of IgA nephropathy.
|
12164881 |
2002 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
We investigated whether the therapeutic efficacy of angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin receptor blocker on renal prognosis is modified by the angiotensinogen gene (AGT) polymorphism in immunoglobulin A nephropathy (IgAN).
|
12911556 |
2003 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the therapeutic efficacy of angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin receptor blocker on renal prognosis is modified by the angiotensinogen gene (AGT) polymorphism in immunoglobulin A nephropathy (IgAN).
|
12911556 |
2003 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The effects of pIgA1 on the RAS were further examined in HMC incubated with IgA isolated from 30 patients with IgAN, 30 healthy subjects, and disease control subjects with other diseases. pIgA1 induction of angiotensin II or TGF-beta synthesis in HMC was significantly greater with preparations from patients with IgAN, compared with healthy or disease control subjects.
|
14638911 |
2003 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently it was reported that polymorphism at -20 from adenine to cytosine in the angiotensinogen gene, increasing the level of this transcript, was associated with the progression of renal dysfunction in adult IgA nephropathy.
|
14648325 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Recently it was reported that polymorphism at -20 from adenine to cytosine in the angiotensinogen gene, increasing the level of this transcript, was associated with the progression of renal dysfunction in adult IgA nephropathy.
|
14648325 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that angiotensinogen-M235T polymorphism is an important marker of progression in IgA nephropathy in Caucasian patients, especially when analyzed in combination with ACE-I/D polymorphism.
|
15031629 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among the ACE, AGT and ATR gene polymorphisms, only the DD genotype may predispose the individual to IgAN in our Chinese population.
|
15153745 |
2004 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current approach to suppress the effects of angiotensin II, by angiotensin-converting enzyme inhibitors, angiotensin II receptor type 1 blockers, or both, as a cornerstone of the therapy of IgA nephropathy has been strengthened by recent studies.
|
15202611 |
2004 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preliminary studies showed a reduced glomerular gene expression of angiotensin II subtype 1 receptor (AT1R), suggesting a regulatory response to high intrarenal angiotensin II (Ang II) concentration in IgAN.
|
15458433 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, and the angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with IgA nephropathy (IgAN) and its progression.
|
15504143 |
2004 |
IGA Glomerulonephritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that activated glomerular AGT expression is likely involved in elevated local ang II production and, thereby, may contribute to increased TGF-beta production and development of glomerular injury in IgAN.
|
18421480 |
2008 |
IGA Glomerulonephritis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Immunohistochemistry showed that AGT protein was highly expressed by glomerular endothelial cells (GEC) and mesangial cells in nephritic glomeruli of IgAN compared with glomeruli of MGA.
|
18421480 |
2008 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human proximal tubular epithelial cells (PTEC) were pretreated with PPAR-gamma agonist, rosiglitazone, and/or angiotensin II (AngII) type 1 receptor (ATR1) blocker (ARB), losartan, followed by activation with the conditioned medium collected from human mesangial cells incubated with pIgA1 (IgA-HMC) from patients with IgAN.
|
19443277 |
2009 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the AGT M235T polymorphism is associated with the progression of IgAN in Korean male patients.
|
19729965 |
2009 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of polymorphisms of the genes encoding major angiotensin II-forming enzymes with the development and progression of IgAN among Korean patients.
|
21150220 |
2011 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, the aldosterone synthase (CYP11B2) gene, C-344T, and the angiotensin II type 1 receptor (AT1R) gene, A1166C, have been shown to be associated with IgA nephropathy (IgAN) and its progression.
|
21163122 |
2010 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone.
|
21974877 |
2011 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ACE, AGT, and eNOS genes were correlated with the development of renal function failure in IgAN, whereas the ACE and eNOS genes were associated with the degree of proteinuria and the development of renal function failure in MN.
|
24157068 |
2013 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, AGT M235T gene polymorphism may not be correlated with IgAN susceptibility in overall populations, Caucasians and Asians.
|
24344785 |
2014 |