Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Losartan, an angiotensin II receptor blocker, has been widely used as the first choice of treatment in chronic renal diseases.
|
28146117 |
2017 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In CKD, concomitant use of iron preparations (OR = 0.3, 95% CI: 0.2-0.7; P-value = 0.002) and of high dosage of angiotensin-converting enzyme inhibitors/angiotensin II-receptor blockers (OR = 0.5, 95% CI: 0.3-0.9; P-value = 0.022) were protective factors against ESA hyporesponsiveness.
|
31521117 |
2019 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are used primarily to treat hypertension and are also useful for conditions such as heart failure and chronic kidney disease, independent of their effect on blood pressure.
|
31498767 |
2019 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This paper describes such a mouse model of CKD utilizing angiotensin II and deoxycorticosterone acetate as inducers.
|
26064882 |
2015 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This short article will focus on the role of the augmented intrarenal angiotensinogen in the pathophysiology of hypertension and chronic kidney disease.
|
22918624 |
2013 |
Chronic Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The increased protein-bound uremic toxin, parathyroid hormone, glucocorticoid, and angiotensin II levels that are observed in CKD all have a negative effect on muscle mass and endurance.
|
31474705 |
2019 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
To assess the clinical effectiveness of beta-blocker therapy in individuals with heart failure (HF) and chronic lung disease and of angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) in individuals with HF and chronic kidney disease.
|
28873219 |
2017 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show that ER stress inhibition through 4-phenylbutyric acid (4-PBA) administration decreases blood pressure, albuminuria, and tubular casts in an angiotensin II/deoxycorticosterone acetate/salt murine model of CKD.
|
28148966 |
2017 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic variants in the angiotensinogen, angiotensin II type 1 receptor and alpha-adducin genes may contribute to loss of renal function in the general female Caucasian population.
|
19274077 |
2009 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The statement, that AGT may be a good biomarker of CKD after acute kidney injury due to HUS requires prospective studies with follow-up from the acute phase of the disease on a larger group of patients.
|
27982687 |
2017 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Subjects carrying the CYP11B2 TT genotype had a higher odds ratio (OR), 1.39 (0.96-2.01), of CKD; while those with the AGT(A[-20]C) CC genotype had an inverse OR of CKD (0.20 (0.05-0.81)), and a high-risk genotype was defined as A/A+A/C for AGT(A[-20C]) and T/T for CYP11B2(C[-344]T).
|
24907556 |
2014 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
ACE2 and NEP generate renoprotective angiotensin (1-7) from angiotensin II and angiotensin I, respectively, and therefore could have a major role in chronic kidney disease (CKD).
|
29561187 |
2018 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
<b>Abbreviations</b>: Angiotensin-converting enzyme (ACE); Angiotensin converting enzyme inhibitors (ACEIs); Angiotensin II (ANG II); Analysis of variance (ANOVA); Angiotensin receptor blockers (ARBs); Blood Pressure (BP); Calcium Antagonists Calcium Channel Blockers (CCB); Chronic kidney diseases (CKD); Sodium carboxyl methyl cellulose (CMC-Na); Cardiac mass index (CMI); Cardiovascular diseases (CVD); Diastolic blood pressure (DBP); Enzyme-linked immunosorbent assay (ELISA); Hematoxylin-eosin (H&E); Kidney mass index (KMI); Liver mass index (LMI); Mean arterial blood pressure (MAP); Plasma renin concentration (PRC); Renin-angiotensin system (RAS); Rennin (REN); Systolic blood pressure (SBP); Student-Newman-Keuls q test (SNK-q test); Spontaneous hypertension rats (SHR); Valsartan asleep Administration (VSA); Valsartan awake Administration (VWA); Wistar-Kyoto (WKY); Mesor (M); Amplitude (A); Phase (φ).
|
31096810 |
2019 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609-0.965).
|
29296205 |
2017 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: risk of chronic renal failure. End-Stage Renal Disease Study Group.
|
10916074 |
2000 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Because activation of the renin-angiotensin system (RAS) is a contributor to CKD progression, we tested our hypothesis by studying the interactions between adiponectin and angiotensin II (ANG II) in renal tubular cells.
|
23535586 |
2013 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Angiotensin II (Ang II) is a risk factor for the initiation and progression of chronic kidney disease (CKD), as elevated Ang II levels can lead to podocyte injury.
|
28878222 |
2017 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Albuminuria correlated positively with urinary angiotensinogen and renin excretions in ADPKD and CKD.
|
28747358 |
2017 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Studies have reported that irbesartan (Irbe), an angiotensin II receptor blocker (ARB) widely prescribed for CKD, activates hepatic PPARα.
|
27496805 |
2016 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Using Cox regression analysis, hazard ratios (HRs) were estimated after adjusting for the following covariates: age, sex, diabetes mellitus, diabetic nephropathy, cardiovascular disease, anemia, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists, loop diuretics, cigarette smoking, body mass index, serum albumin, systolic blood pressure, urine albumin-to-creatinine ratio, and CKD stage.
|
30168046 |
2019 |
Chronic Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Animal studies suggest that increased levels of circulating angiotensin II (AngII) could contribute to the loss of lean body mass in chronic kidney disease, but the mechanism by which this occurs is unclear.
|
19158350 |
2009 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, our studies reveal that angiotensin II-induced renal CD73 promotes the production of renal adenosine that is a prominent driver of hypertensive CKD by enhanced ADORA2B signaling-mediated endothelin-1 induction in a hypoxia-inducible factor-α-dependent manner.
|
23584256 |
2013 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results highlight the importance of AngII as a driver of resistance vessel structural, functional, and biomechanical dysfunction and provide insight as to how AT1 receptor blockade exerts therapeutic efficacy in CKD.
|
29425281 |
2018 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Polymorphism of the genes associated with angiotensin, including angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and the type 1 (AT1) and type 2 (AT2) angiotensin II receptors, has been implicated in the pathophysiology of hypertension, ischemic heart disease, and progression of chronic renal disease.
|
11544438 |
2001 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite the huge amount of studies looking for candidate genes, the ACE gene remains the unique, well-characterized locus clearly associated with pathogenesis and progression of chronic kidney disease, and with response to treatment with drugs that directly interfere with the renin angiotensin system (RAS), such as angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists (ARA).
|
18550651 |
2008 |