Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke.
|
17299437 |
2007 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the evolution with age of the frequencies of the I/D polymorphism of the angiotensin I-converting enzyme (ACE), a1166c of the angiotensin II AT1 receptor (AT1R), M235T of the angiotensinogen (AGT) and A225V of their methylenetetrahydrofolate reductase (MTHFR) gene in a healthy (H) population and the subsequent comparison to age- and sex-matched groups of myocardial infarction (MI) subjects.
|
10488956 |
1999 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the T174M polymorphism in the AGT gene may be related to an increased risk of MI.
|
25966146 |
2015 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor (TGF)-β1 contributed to angiotensin II (Ang II)-mediated collagen accumulation after myocardial infarction (MI).
|
31147455 |
2019 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Gene polymorphisms of angiotensinogen and angiotensin-converting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction.
|
12444540 |
2002 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Already the angiotensin converting enzyme and the angiotensinogen genes have been implicated in myocardial infarction and hypertension.
|
7700002 |
1994 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increase in inflammatory cytokines synthesis coincides with activation of microglia within PVN of angiotensin II-induced hypertensive model and myocardial infarction-induced heart failure model.
|
26874752 |
2017 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the authors provide evidence of an interactive effect on MI risk between risk genotypes of RAS, as well as between the angiotensinogen-TT genotype and metabolic risk factors.
|
11330506 |
2001 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Excessive activation of the β-adrenergic, angiotensin II (Ang II) and aldosterone signaling pathways promotes mortality after myocardial infarction, and antagonists targeting these pathways are core therapies for treating this condition.
|
22081025 |
2011 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that neither the DD genotype of the ACE I/D polymorphism nor the T174 and T235 homozygotes of the AGT gene confer significant risk for CAD or MI in Chinese.
|
9254851 |
1997 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we describe the use a highly selective TG2 small-molecule inhibitor to test the efficacy of TG2 inhibition as an anti-fibrotic therapy for heart failure employing two different in vivo models of cardiac fibrosis: Progressively induced interstitial cardiac fibrosis by pressure overload using angiotensin II infusion: Acutely induced focal cardiac fibrosis through myocardial infarction by ligation of the left anterior descending coronary artery (AMI model).
|
29795262 |
2018 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No associations were detected between AGT M235T and the risk of MI in total population and Caucasians.
|
23283824 |
2014 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Exciting new discoveries concerned with polymorphisms of genes coding for angiotensin converting enzyme (ACE) and angiotensinogen suggest that Ang II may be genetically associated with increased risk for myocardial infarction, hypertension and left ventricular hypertrophy.
|
8583476 |
1995 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the role of haplotypes formed by these polymorphisms for angiotensinogen levels we examined blood pressure, coronary artery disease (CAD), myocardial infarction (MI), and AGT genotypes and haplotypes in 2,575 patients with angiographically documented CAD and 731 individuals in whom CAD had been ruled out by angiography.
|
15599691 |
2005 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was a significant association between (CA)n polymorphism of the AGT gene and the extent of CAD in Greek patients with a history of MI.
|
20529973 |
2010 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We determined the effects of spermidine in a model of MI, Sprague-Dawley rats with permanent ligation of the left anterior descending artery, and in cultured neonatal rat cardiomyocytes (NRCs) exposed to angiotensin II (Ang II).
|
31077347 |
2019 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991.
|
21167013 |
2012 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the present study was to assess whether the insertion (I)/deletion (D) polymorphism of the angiotensin converting enzyme (ACE) gene, and the polymorphism of angiotensinogen (AGT) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) were associated with left ventricular dilatation after myocardial infarction.
|
8793580 |
1996 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease.
|
11352695 |
2001 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease.
|
20945963 |
2011 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cav3 was experimentally confirmed as a direct target of miR-22, containing two seed binding sites in its 3'-untranslated region, and miR-22 was demonstrated to be significantly upregulated in the ischemic border zone in mice after myocardial infarction and in neonatal rat CFs pretreated with angiotensin II. miR-22 overexpression increased CFs proliferation, and collagen and α-smooth muscle actin levels in CFs, while the knockdown of endogenous miR-22 decreased CFs numbers.
|
29486470 |
2018 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Angiotensin-Converting Enzyme Inhibitors Provide Better Long-Term Survival Benefits to Patients With AMI Than Angiotensin II Receptor Blockers After Survival Hospital Discharge.
|
30130974 |
2018 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The angiotensin II type 2 (AT2) receptor is thought to play a role in cardiovascular disorders such as neointima formation after vascular injury, cardiac hypertrophy and myocardial infarction (MI).
|
12453540 |
2002 |
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In East Asian group, significant association was found between AGT M235T polymorphism and risk of MI (for dominant model: OR=1.79; 95% CI=1.04-3.06; for recessive model OR=2.01; 95% CI=1.21-3.36; for additive model OR=1.79; 95% CI=1.14-2.86) as well as BI (for dominant model: OR=1.66; 95% CI=1.22-2.27; for recessive model OR=1.78, 95% CI=1.29-2.46; for additive model: OR=1.64, 95% CI=1.34-2.00), while the M235T polymorphism did not impact the risk of MI in total population and other ethnicity.
|
23933419 |
2013 |
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Enzyme-linked immunosorbent assay (ELISA) analysis showed that QLQX significantly reduced the levels of angiotensin II (AngII), brain natriuretic peptides (BNP), creatinine (CRE), cystatin C (CysC), tumor necrosis factor (TNF)-α, interleukin (IL)-6, microalbuminuria (MAU), and neutrophil gelatinase-associated lipocalin (NGAL) in plasma induced by myocardial infarction.
|
30068867 |
2018 |