|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The impact of polymorphisms in the genes coding for angiotensinogen (M235T), ACE (ID), and angiotensin II type 1 receptor (A(1166)-->C) on decline in GFR and doubling of s-creatinine or development of ESRD in patients with type 1 diabetes and diabetic nephropathy (DN) was tested.
|
14569094 |
2003 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that neither the M235T nor the T174M polymorphism in the angiotensinogen gene contributes to genetic susceptibility to diabetic nephropathy in white IDDM patients, whereas the TT genotype of the M235T is associated with elevated blood pressure in patients with diabetic nephropathy.
|
8593944 |
1996 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Neither the AGT TT genotype nor the T allele were associated with the progression of DN in either sex after adjusting for confounding factors.
|
18849600 |
2009 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
DNA polymorphism M235T in the angiotensinogen gene, which is associated with higher expression of this gene, contributes to the risk of diabetic nephropathy in NIDDM men but not in women.
|
9535411 |
1998 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A substitution (M235T) polymorphism in angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic nephropathy, but their prognostic values have to be established by follow-up studies.
|
11181802 |
2001 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Allelic frequencies of the ACE-D and AGT-235T alleles were similar between patients with and without nephropathy in either type of diabetes, and accordingly, there was no significant association between diabetic nephropathy and the ACE or AGT genotype.
|
9049480 |
1997 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 102 individuals were screened for the presence of the ACE I/D and AGT M235T polymorphism: 46 individuals who had type 2 DM with diabetic nephropathy and, as controls, 56 individuals who had type 2 DM without diabetic nephropathy.
|
18413162 |
2008 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene-gene interaction between acetyl-coenzymeA carboxylase beta (ACACβ) gene, which is involved in fatty acid metabolism and angiotensin II receptors (AGTR1) gene, which mediates RAS proteins actions on renal tissue, polymorphism with DN have not been studied earlier.
|
23081748 |
2013 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study has shown that AGT M235T TT genotype and APO E ε 2/3 genotype may be linked to a risk for DN among Turkish population.
|
21500980 |
2011 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the role of the renin-angiotensin system (RAS) in diabetic nephropathy, we examined the association between diabetic nephropathy in a large cohort of Japanese type 2 diabetic patients and polymorphisms within the genes that encode angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II receptor type 1 (AGTR1).
|
17143591 |
2007 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that ACE I/D polymorphism, but not AGN M235T polymorphism, is a possible genetic risk factor for diabetic nephropathy in Japanese NIDDM patients.
|
8596493 |
1996 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM.
|
8772723 |
1996 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Conflicting results on the relationship between M235T polymorphism of angiotensinogen (AGT) gene and diabetic nephropathy are reported in the literature, probably due to the small number of subjects, to different inclusion criteria and the different genotype analysis methods used.
|
12270765 |
2002 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ACE and AGT gene polymorphisms may not play a role in the protective or accelerative effect against the development of diabetic nephropathy in the patients with or without proliferative retinopathy, but ACE gene polymorphism might be related to an arteriosclerotic family history in Japanese IDDM patients.
|
10499884 |
1999 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we investigated the long-term effect of the angiotensin II subtype-1 (AT1) receptor antagonist losartan (100 mg o.d.) on kidney function in II and DD type 1 diabetic patients with diabetic nephropathy.
|
12716812 |
2003 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive electronic search in Pubmed, Web of Science, EBSCO, Embase, the Cochrane Library and China National Knowledge Infrastructure (CNKI) to find original articles about the association between AGT M235T polymorphism and DN risk published before 27 September 2017.
|
29775675 |
2018 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study is a continuation of our previous research on the association between angiotensinogen (AGT) gene polymorphisms and DN in patients with T2DM.
|
29514038 |
2018 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
DN (+) DUR < 5 years group had greatly increased frequencies of AGT-M235T allele and ACE-DD genotype in comparison with DN(-) group (0.92 vs 0.68 and 0.28 vs 0.05, respectively).
|
11776100 |
2000 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The regions containing ACE and AGT loci were not linked with DN, while the region containing the AT1 locus showed linkage with DN.
|
9648845 |
1998 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy.
|
8877296 |
1996 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The data do not support a role of ACE (DD/II) or Atg M235T polymorphism in the development of diabetic nephropathy in Chinese patients with type II diabetes, and no synergistic effect was found between them.
|
10352194 |
1999 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comparison of haplotype frequencies identified the rare AGT haplotype as significantly protective against DN, 3.1% cases versus 5.8% controls; chi(2) = 11.05, Pc = 0.009 by the permutation test.
|
19783860 |
2010 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.
|
30798724 |
2019 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AGT rs699 and rs4762 missense polymorphisms are not associated with DN in our subset of Slovenian T2DM patients.
|
28488548 |
2017 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin I-converting enzyme and angiotensinogen gene polymorphisms in non-insulin-dependent diabetes mellitus. Lack of relationship with diabetic nephropathy and retinopathy in a Caucasian Mediterranean population.
|
9258285 |
1997 |