|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Presently, ACE and AGT are the only gene variants with functional relevance, where linkage studies showing relationships with hypertension have been reproduced in some studies and where large population-based and prospective studies have demonstrated these genes to be predictors of hypertension or BP.
|
20088829 |
2010 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our meta-analysis indicated significant association between angiotensinogen promoter polymorphisms and hypertension in the Chinese populations, especially in Han Chinese.
|
22216295 |
2011 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Variation in AGT (rs2004776) was associated with systolic blood pressure (β: 0.42 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=3.8×10(-6)), as well as diastolic blood pressure (P=5.0×10(-8)) and hypertension (P=3.7×10(-7)).
|
21444836 |
2011 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
So, the aim of current study was to develop efficient low-cost method for genotyping of cardiovascular disease and hypertension associated polymorphisms of AGT (rs4762, rs5051) and CYP11B1 (rs6410).
|
30478747 |
2019 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.
|
10608470 |
1999 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Variants of the angiotensinogen gene may increase the risk of having arterial hypertension and coronary heart disease (CHD), but their effect on insulin resistance remains unknown.
|
9665229 |
1998 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This study aimed to examine genetic associations between hypertension and the M235T, T174M, and G-217A polymorphisms of the angiotensinogen gene in Chinese siblings.
|
20216084 |
2010 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A relation between the angiotensinogen gene locus and hypertension has been found in whites, Japanese, and African Caribbeans but not in Chinese.
|
10489389 |
1999 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We mainly focused on gene components of the renin-angiotensin system as candidates, finding that angiotensinogen gene polymorphisms are genetic predisposing factors for hypertension.
|
10865821 |
2000 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We cannot exclude the possibility that the observed association in the nephropathy group is due to an association between AGT genotype and hypertension.
|
8772723 |
1996 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Both in rat and human, the genetic predisposition to hypertension was confirmed only for angiotensinogen and alpha-adducin genes.
|
9607391 |
1998 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Although AGT gene variants had no independent effects on either the presence of hypertension or ABP values in hypertensives, the -20A-->C polymorphism had a marked influence on the relation between ambulatory systolic BP and BMI.
|
12234952 |
2002 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
There is clear evidence that polymorphisms at the renin, angiotensinogen, and angiotensin-converting enzyme loci influence both blood pressure and hypertension.
|
10453099 |
1999 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
We also screened angiotensinogen gene AGT M235T and angiotensin-converting enzyme insertion/deletion polymorphism ACE I/D and found an association between TT genotype and hypertension.
|
18758497 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
|
12805070 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study.
|
18957799 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We examined the association between variants in the core promoter element 1 (AGCE1) of the human angiotensinogen gene (AGT), which acts as a critical regulator of AGT transcription, and the risk for hypertension.
|
9314411 |
1997 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
AGT TT genotype was associated with a 48% decrease in the risk of having hypertension (odds ratio: 0.52; 95% CI, 0.28 to 0.96), and this risk decreased more significantly in women (odds ratio: 0.28; 95% CI, 0.1 to 0.78).
|
15642127 |
2005 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
[Polymorphism of the promotor region of the angiotensinogen gene and the gene for angiotensin I-converting enzyme in arterial hypertension and myocardial ischemia of the Kazakh ethnic groups].
|
12669427 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The aim of our study was the analysis of M235T mutation in the gene encoding angiotensinogen in Romanian women with different forms of hypertension during pregnancy.
|
12417054 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease.
|
20945963 |
2011 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
These data suggest that the AGT gene could be involved in the predisposition to high blood pressure in non-overweight, but not in overweight men, possibly reflecting genetically different types of hypertension.
|
7622852 |
1995 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The insertion of mouse renin gene (Ren-2) into the genome of normotensive rats causes a spontaneous rise of blood pressure (BP), leading to an angiotensin II (Ang II)-dependent form of hypertension in transgenic (mRen-2)27 rats (TGR).
|
31037948 |
2019 |