AGT, angiotensinogen, 183

N. diseases: 765; N. variants: 43
Disease: Fetal Growth Retardation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 AlteredExpression phenotype BEFREE Expression of prorenin, AGT, angiotensin converting enzyme (ACE) or ACE2 proteins were similar in control and FGR placentae. 31247590 2019
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 Biomarker phenotype BEFREE Studies in animal models mimicking the pattern and level of increase of adult female testosterone levels to those found in preeclamptic pregnancies, replicate key features of preeclampsia, including gestational hypertension, endothelial dysfunction, exaggerated vasoconstriction to angiotensin II, reduced spiral artery remodeling, placental hypoxia, decreased nutrient transport and fetal growth restriction. 30325182 2018
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 Biomarker phenotype BEFREE Renin and angiotensinogen both decreased in the FGR group. 27534427 2016
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 Biomarker phenotype RGD Evaluation of kidney dysfunction and angiotensinogen as an early novel biomarker of intrauterine growth restricted offspring rats. 26270574 2015
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 AlteredExpression phenotype BEFREE Our study suggested increased apoptosis and decreased renin and angiotensinogen expression during human kidney development in an FGR environment. 25271252 2015
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 Biomarker phenotype CTD_human Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring. 17537837 2007
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 Biomarker phenotype BEFREE There were no statistically significant differences between intrauterine growth restriction (IUGR) and appropriate for gestational age (AGA) newborns in respect to renin, angiotensinogen and ACE gene expressions. 17851801 2007
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 GeneticVariation phenotype BEFREE Altered transmission of maternal angiotensin II receptor haplotypes in fetal growth restriction. 16395664 2006
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 Biomarker phenotype BEFREE Inherited thrombophilia, such as factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase mutations; gene polymorphisms of detoxification enzyme (CYP1A1); growth factors (insulin-like growth factor-I); and hormones such as angiotensinogen and CYP17 are involved in the pathogenesis of fetal growth restriction. 16052406 2005
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 Biomarker phenotype BEFREE An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation. 14688210 2004
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 AlteredExpression phenotype BEFREE In contrast, levels of the angiotensin II receptor were elevated in preeclampsia and reduced in IUGR subjects, as shown by RT-PCR and Western blotting analysis. 12519878 2003
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 GeneticVariation phenotype BEFREE We genotyped maternal and fetal deoxyribonucleic acid (DNA) for angiotensinogen Thr235 to estimate whether the polymorphism is also a risk factor for intrauterine growth restriction. 12576245 2003
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.600 AlteredExpression phenotype BEFREE Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants. 9435317 1998