AGT, angiotensinogen, 183

N. diseases: 765; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The angiotensin II (ANG II)-ANG II type 1 receptor (AT<sub>1</sub>R) axis is a key player in the pathophysiology of obesity. 31638856 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm. 30404738 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE We investigated renin-angiotensin system (RAS) activity in cultured circulating T-cells in subjects with obesity with and without angiotensin II (Ang II) stimulation in the presence or absence of low-grade inflammation. 31084908 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE We have previously reported that adipose overexpression of angiotensinogen in mice (Agt-Tg) induces obesity, in part mediated by adipose tissue inflammation, through yet unidentified mechanisms. 31186446 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE The expression of angiotensinogen and AT1 was downregulated by obesity, while neutral endopeptidase and AT2 expressions were upregulated in obese rats with aging. 31197649 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Factors that contribute to increased sodium reabsorption in obesity include kidney compression by visceral, perirenal and renal sinus fat; increased renal sympathetic nerve activity (RSNA); increased levels of anti-natriuretic hormones, such as angiotensin II and aldosterone; and adipokines, particularly leptin. 31015582 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children. 28337615 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Since RAAS over activity contributes to hypertension in obesity, we have made transgenic mice (TG) containing either Hap I or Hap II of the hAGT gene to understand the role of obesity on its transcriptional regulation. 28467442 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Seven-week hypercaloric diet-induced obesity produces alterations in vascular adrenergic and angiotensin II receptor dynamics that suggest an endothelium-dependent adrenergic/angiotensin II crosstalk. 28783954 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE In this study, we employed TaqMan genotyping assays to evaluate the role of 8 AGT variants in primary hypertension (HTN), type 2 diabetes mellitus (T2DM), and obesity as a possible trigger of coronary artery disease (CAD) in a population of 4615 angiographed native Saudi individuals. 23497386 2013
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity. 21779803 2012
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE The aims of the study were (i) to assess the distribution of the angiotensin II type 1 receptor (AGTR1) gene 1166A/C polymorphism and two polymorphisms of the angiotensinogen (AGT) gene (Met235Thr and Thr174Met) in patients with ST-segment-elevation myocardial infarction (STEMI) who underwent coronary angiography, compared with healthy volunteers; (ii) to determine if there was any correlation between these polymorphisms and risk of STEMI; and (iii) to assess the association of the examined polymorphisms with such classic cardiovascular risk factors as hypertension, diabetes mellitus, obesity (based on a body mass index ≥25 kg/m2), smoking, dyslipidemia, and family history of cardiovascular disease. 21657802 2011
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Using a mouse model of obesity and weight reduction, plasma AGT levels were measured with a newly developed enzyme-linked immunosorbent assay (ELISA), and the contribution of A-AGT-S to plasma AGT levels was assessed. 20057360 2010
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Adipose tissue AGT mRNA level in obese mice was also lower as compared with their lean littermates; however, the hepatic AGT mRNA level remained unchanged. 20045538 2010
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE In obesity, adipose tissue undergoes inflammatory infiltration and the subsequent higher levels of pro-inflammatory angiotensin II may explain this association. 17624939 2007
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE The genotype frequencies of AGT M235T polymorphism were in accordance with the Hardy-Weinberg equation (obese: M/M, 6.7%; M/T, 27.5%; T/T, 65.8%; control: M/M, 6.8%; M/T, 21.2%; T/T, 71.9%). 16713443 2006
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Subjects who carry the D allele of the angiotensin-converting enzyme (ACE) gene have higher plasma and tissue angiotensin II levels, possibly concurrent with the development of obesity. 15912101 2005
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Adipose GR-alpha and angiotensinogen mRNA levels were not associated with obesity or insulin resistance, but leptin mRNA was positively related to 11HSD1 activity (SBC = 0.59; P < 0.05) and tended to be associated with parameters of obesity (BMI: SBC = 0.40; P = 0.09), fasting insulin (SBC = 0.65; P < 0.05), and 11HSD1 mRNA (SBC = 0.40; P = 0.15). 12915696 2003
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE In conclusion, the M235T angiotensinogen gene polymorphism is considered alone as well as in interaction with obesity to be risk factors for EAH in childhood. 12597535 2002
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE In addition, the expression of angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1) genes was studied in sc adipose tissue from 8 obese, 6 hypertensive obese and 6 healthy subjects. 12030600 2002
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Thus, obesity is associated with the activation of renal ACE in vivo independent of its mRNA expression and enhanced vascular contractility to angiotensin II. 10642320 2000
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Adipose angiotensinogen gene expression is elevated in obesity in men. 10933310 2000
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Considering cardiovascular diseases there is a number of genes involved in lipid metabolism (apolipoproteins, lipoprotein receptors, lipolytic enzymes), thrombosis/hemostasis (platelet receptors, pro- and anticoagulant proteins, fibrinogen, PAI's), hypertension (angiotensin converting enzyme, angiotensinogen) glucose metabolism (glucose transporters, enzymes) and obesity (hormones, receptors), that are interesting candidates for sophisticated genetic risk assessment. 9654602 1998
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE These data suggest that obesity may alter the levels of ACE and angiotensinogen, and provide a potential pathway through which obesity leads to elevation of BP. 9140797 1997
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity. 8728297 1996