Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The angiotensin II (ANG II)-ANG II type 1 receptor (AT<sub>1</sub>R) axis is a key player in the pathophysiology of obesity.
|
31638856 |
2019 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm.
|
30404738 |
2019 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated renin-angiotensin system (RAS) activity in cultured circulating T-cells in subjects with obesity with and without angiotensin II (Ang II) stimulation in the presence or absence of low-grade inflammation.
|
31084908 |
2019 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have previously reported that adipose overexpression of angiotensinogen in mice (Agt-Tg) induces obesity, in part mediated by adipose tissue inflammation, through yet unidentified mechanisms.
|
31186446 |
2019 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of angiotensinogen and AT1 was downregulated by obesity, while neutral endopeptidase and AT2 expressions were upregulated in obese rats with aging.
|
31197649 |
2019 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Factors that contribute to increased sodium reabsorption in obesity include kidney compression by visceral, perirenal and renal sinus fat; increased renal sympathetic nerve activity (RSNA); increased levels of anti-natriuretic hormones, such as angiotensin II and aldosterone; and adipokines, particularly leptin.
|
31015582 |
2019 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children.
|
28337615 |
2017 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since RAAS over activity contributes to hypertension in obesity, we have made transgenic mice (TG) containing either Hap I or Hap II of the hAGT gene to understand the role of obesity on its transcriptional regulation.
|
28467442 |
2017 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seven-week hypercaloric diet-induced obesity produces alterations in vascular adrenergic and angiotensin II receptor dynamics that suggest an endothelium-dependent adrenergic/angiotensin II crosstalk.
|
28783954 |
2017 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we employed TaqMan genotyping assays to evaluate the role of 8 AGT variants in primary hypertension (HTN), type 2 diabetes mellitus (T2DM), and obesity as a possible trigger of coronary artery disease (CAD) in a population of 4615 angiographed native Saudi individuals.
|
23497386 |
2013 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity.
|
21779803 |
2012 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aims of the study were (i) to assess the distribution of the angiotensin II type 1 receptor (AGTR1) gene 1166A/C polymorphism and two polymorphisms of the angiotensinogen (AGT) gene (Met235Thr and Thr174Met) in patients with ST-segment-elevation myocardial infarction (STEMI) who underwent coronary angiography, compared with healthy volunteers; (ii) to determine if there was any correlation between these polymorphisms and risk of STEMI; and (iii) to assess the association of the examined polymorphisms with such classic cardiovascular risk factors as hypertension, diabetes mellitus, obesity (based on a body mass index ≥25 kg/m2), smoking, dyslipidemia, and family history of cardiovascular disease.
|
21657802 |
2011 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using a mouse model of obesity and weight reduction, plasma AGT levels were measured with a newly developed enzyme-linked immunosorbent assay (ELISA), and the contribution of A-AGT-S to plasma AGT levels was assessed.
|
20057360 |
2010 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adipose tissue AGT mRNA level in obese mice was also lower as compared with their lean littermates; however, the hepatic AGT mRNA level remained unchanged.
|
20045538 |
2010 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In obesity, adipose tissue undergoes inflammatory infiltration and the subsequent higher levels of pro-inflammatory angiotensin II may explain this association.
|
17624939 |
2007 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genotype frequencies of AGT M235T polymorphism were in accordance with the Hardy-Weinberg equation (obese: M/M, 6.7%; M/T, 27.5%; T/T, 65.8%; control: M/M, 6.8%; M/T, 21.2%; T/T, 71.9%).
|
16713443 |
2006 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Subjects who carry the D allele of the angiotensin-converting enzyme (ACE) gene have higher plasma and tissue angiotensin II levels, possibly concurrent with the development of obesity.
|
15912101 |
2005 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adipose GR-alpha and angiotensinogen mRNA levels were not associated with obesity or insulin resistance, but leptin mRNA was positively related to 11HSD1 activity (SBC = 0.59; P < 0.05) and tended to be associated with parameters of obesity (BMI: SBC = 0.40; P = 0.09), fasting insulin (SBC = 0.65; P < 0.05), and 11HSD1 mRNA (SBC = 0.40; P = 0.15).
|
12915696 |
2003 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the M235T angiotensinogen gene polymorphism is considered alone as well as in interaction with obesity to be risk factors for EAH in childhood.
|
12597535 |
2002 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the expression of angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1) genes was studied in sc adipose tissue from 8 obese, 6 hypertensive obese and 6 healthy subjects.
|
12030600 |
2002 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, obesity is associated with the activation of renal ACE in vivo independent of its mRNA expression and enhanced vascular contractility to angiotensin II.
|
10642320 |
2000 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adipose angiotensinogen gene expression is elevated in obesity in men.
|
10933310 |
2000 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Considering cardiovascular diseases there is a number of genes involved in lipid metabolism (apolipoproteins, lipoprotein receptors, lipolytic enzymes), thrombosis/hemostasis (platelet receptors, pro- and anticoagulant proteins, fibrinogen, PAI's), hypertension (angiotensin converting enzyme, angiotensinogen) glucose metabolism (glucose transporters, enzymes) and obesity (hormones, receptors), that are interesting candidates for sophisticated genetic risk assessment.
|
9654602 |
1998 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that obesity may alter the levels of ACE and angiotensinogen, and provide a potential pathway through which obesity leads to elevation of BP.
|
9140797 |
1997 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity.
|
8728297 |
1996 |