Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris.
|
31774569 |
2020 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The BIOCHIP was found to have a sensitivity of 60.9% and specificity of 73.6% for Dsg3 in PV.
|
31260565 |
2020 |
Pemphigus Vulgaris
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Among the large number of studied SNPs, it was found that several SNPs in different genes might control the susceptibility of PV, including TNFA (rs361525, rs1800629, rs1800629), IL10 (rs1800871, rs1800896, rs1800871, and rs1800872), IL6 (rs1800795), CTLA4 (rs231775), ICOS (rs10932029), CD86 (rs1129055), DSG3 (rs8085532, rs3911655, rs3848485, rs3794925, rs1466379), ST18 (rs2304365, rs17315309) and TAP2 (rs7454108), probably in a population-specific manner.
|
31342641 |
2020 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Desmoglein 3, the target antigen of pemphigus vulgaris, an IgG-mediated autoimmune blistering disease, was used in a HaloTag protein barcode assay to detect the anti-DSG3 antibody.
|
31752022 |
2020 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
The mucosal-dominant subtype of PV (mdPV) is caused by PV-IgG autoantibodies against the cadherin-type adhesion molecule Dsg3. p38 mitogen-activated protein kinase (p38MAPK) signalling has been characterized as an important pathway downstream of PV-IgG binding and its inhibition is protective in ex vivo human skin.
|
31218663 |
2020 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Sera from patients with PV contained significantly greater levels of anti-Dsg3 autoantibodies than walnut-specific antibodies, suggesting that the autoreactive B-cell response in patients with PV might be initially triggered by walnut antigens but is subsequently driven by Dsg3.
|
31071340 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Dsg3- but not Dsg2-deficient cells were protected against PV-IgG-induced loss of cell adhesion.
|
31178865 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus.
|
31077459 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, monitoring of Dsg3-specific B cells in PV is of particular interest to further characterize the immunopathogenesis of PV.
|
31258541 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, the inhibitory antibody against Ecad but not a Dsg3-specific PV antibody interfered with stimulated lipid production.
|
31121132 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV).
|
31024527 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
We used three PV-IgG fractions from different patients containing high or low levels of anti-Dsg1 and anti-Dsg3 antibodies, and the presence or not of anti-desmocollin (Dsc) antibodies, using a passive transfer mouse model of PV.
|
31370093 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings suggest a novel role for Dsg3 as an anti-stress protein, via suppression of p53 function, and this pathway is disrupted in PV.
|
31582719 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering sores on skin and mucosal membranes, caused by autoantibodies primarily targeting the cellular adhesion protein, desmoglein-3 (Dsg3).
|
31340153 |
2019 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice.
|
30233569 |
2018 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Identified almost 30 years ago, desmoglein-3 (Dsg3), a Ca<sup>2+</sup>-dependent cell adhesion molecule belonging to the cadherin family, has been considered the "primary" autoantigen in PV.
|
29915578 |
2018 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Antibodies against desmoglein 3 (Dsg3) map to a broader array of epitopes than in pemphigus vulgaris and there is a higher prevalence of complement binding anti-Dsg3 IgG autoantibodies in PAMS.
|
30103046 |
2018 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Desmoglein 3 (DSG3) is highly expressed in lung squamous cell carcinoma, while it is well-known that anti-DSG3 antibodies cause pemphigus vulgaris, an autoimmune disease.
|
30239818 |
2018 |
Pemphigus Vulgaris
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cells share lineages with IgG1, IgA1, and IgA2.
|
30157430 |
2018 |
Pemphigus Vulgaris
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The data showed that miR-338-3p expression was significantly upregulated in PV and the upregulation of miR-338-3p associated with disease severity and a high anti-Dsg3 antibody titer.
|
29749496 |
2018 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
All PV-IgG fractions and AK23 compromised Dsg3 but not Dsg1 binding and enhanced Src activity.
|
28620161 |
2017 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
To define cut-off values for Dsg1, Dsg3, and BP180, we evaluated 47 serum samples from patients with pemphigus foliaceus (PF), 59 from those with pemphigus vulgaris (PV), 52 from those with bullous pemphigoid (BP), and 995 from healthy individuals.
|
28012821 |
2017 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, it seems likely that autoreactive B cells reside and produce autoantibodies in these tissues.Yuan et al. analyzed lymphocytes in the lesional skin of patients with pemphigus vulgaris using several experimental techniques and concluded that desmoglein 3-reactive B cells were present.
|
29055412 |
2017 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3.
|
28321152 |
2017 |
Pemphigus Vulgaris
|
0.300 |
Biomarker
|
disease |
BEFREE |
Human skin samples were injected with IgG fractions of one patient suffering from mucocutaneous PV (mcPV-IgG), one from mucosal-dominant PV (mdPV-IgG) or AK23, a pathogenic monoclonal Dsg3 antibody derived from a pemphigus mouse model.
|
28600798 |
2017 |