DSG3, desmoglein 3, 1830

N. diseases: 78; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.060 Biomarker disease BEFREE PKP1 and DSG3 are related to the prognosis.<b>Conclusions:</b> PKP1, KRT15, and DSG3 are highly specific for SCC, but they were more useful to differentiate between SCC and AC when used together and in combination with conventional markers. 31809668 2020
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.060 Biomarker disease BEFREE We identified DSG3 (desmoglein 3), KRT5 (keratin 5), KRT6A (keratin 6A), KRT6B (keratin 6B), NKX2-1 (NK2 homeobox 1), SFTA2 (surfactant associated 2), SFTA3 (surfactant associated 3), and TMC5 (transmembrane channel-like 5) as potential biomarkers for distinguishing between LADC and LSCC. 29069744 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.060 Biomarker disease BEFREE Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has recently been shown to be upregulated in squamous cell carcinoma (SCC) and has been identified as a good tumor-specific marker for clinical staging of cervical sentinel lymph nodes in head and neck SCC. 23752190 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.060 Biomarker disease BEFREE The microarray data showed that DSG3 had a sensitivity and specificity of 88% and 98%, respectively, in detecting SQCC versus adenocarcinoma. 19342368 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.060 AlteredExpression disease BEFREE In addition, deltaNDg3 transcript and protein were upregulated in psoriatic epidermis, and protein expression appeared to increase in epidermal tumors including Bowen's disease and squamous cell carcinoma. 19287199 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.060 Biomarker disease BEFREE We previously reported that pemphigus vulgaris (PV)-IgG caused the formation of Dsg3-depleted desmosomes in normal human cultured keratinocytes and DJM-1, a human squamous cell carcinoma cell line. 17431647 2007