DSG3, desmoglein 3, 1830

N. diseases: 78; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris. 31774569 2020
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE In all patients, the mean of pemphigus disease area index (PDAI) decreased from 20.3 ± 14.1 to 0.4 ± 0.0, whereas the mean Dsg3 value dropped from 157.1 ± 40.6 to 67.0 ± 26.6 after therapy with RTX. 31420993 2020
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus. 31077459 2019
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Dsg3 was the commonest positive substrate in pemphigus group (86%) with 100% sensitivity. 31211701 2019
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3. 31057535 2019
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion. 31178865 2019
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Treatment with Pemphigus auto-antibodies results in loss of monolayer integrity and altered localization of desmoglein-3, as well as loss of colocalization with flotillin-2. 31247885 2019
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE In order to verify the pathogenic activity of anti-Desmocollin 3 (DSC3) antibodies, we developed an active disease model of pemphigus expressing anti-DSC3 autoantibodies or anti-DSC3 and anti-DSG3 antibodies. 31275323 2019
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herpetiformis umfassen. 30179341 2018
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA. 29740444 2018
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission. 29145342 2017
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 AlteredExpression disease BEFREE Ethnic group, age at presentation, initial intercellular antibody titre and initial Dsg 3 antibody levels all had a significant impact on prognosis of pemphigus. 24102444 2014
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Taken together, our data indicate that DP phosphorylation at S2849 represents an important mechanism in pemphigus pathogenesis, which, by reversing Ca(2+) insensitivity, promotes Dsg3 depletion. 25010392 2014
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE These observations allow us to propose a concept for pemphigus blistering disorders as a "desmosome-remodeling impairment disease" involving a mechanism of Dsg3 nonassembly and depletion from desmosomes through PV immunoglobulin G-activated intracellular signaling events. 23257250 2013
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE TP did not directly block binding of pemphigus IgG to their target Dsg antigens but prevented PV-IgG-induced inhibition of Dsg3 transinteraction in cell-free (atomic force microscopy) and cell-based (laser tweezer) experiments, indicating stabilization of Dsg3 bonds. 19164289 2009
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Among these, two pathogenic T cell clones induced anti-Dsg3 IgG production and the development of a pemphigus phenotype when adoptively transferred with unprimed B cells from Dsg3(-/-) mice. 19155523 2009
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease LHGDN Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction. 18641320 2008
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease LHGDN Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris. 18586466 2008
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease LHGDN Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis. 17431647 2007
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease LHGDN Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity. 17428808 2007
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE On the other hand, fundamental doubt has been raised towards this monopathogenic view by several independent factors: (1) pemphigus lesions can be induced in Dsg3-knockout (KO) mice; (2) pemphigus sera contain multiple autoantibodies against different adhesion molecules and also cholinergic receptors; (3) experimental inhibition of PV IgG induced acantholysis can be obtained by interference with different signaling cascades regulating both calcium homeostasis and apoptosis; and (4) cholinergic agonists exhibit anti-acantholytic activity both in vitro and in vivo. 17101498 2006
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1. 15841178 2005
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease BEFREE Alternatively, immunization with a combination of dsg3 protein along with other proteins might be necessary to induce pemphigus disease in adult mice. 12653831 2003
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 GeneticVariation disease BEFREE We also showed that the profile of anti-Dsg 1 and/or anti-Dsg 3 autoantibodies is associated with the clinical variant of pemphigus. 14646976 2003
CUI: C0030807
Disease: Pemphigus
Pemphigus
0.100 Biomarker disease LHGDN Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles. 12496453 2003