Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris.
|
31774569 |
2020 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In all patients, the mean of pemphigus disease area index (PDAI) decreased from 20.3 ± 14.1 to 0.4 ± 0.0, whereas the mean Dsg3 value dropped from 157.1 ± 40.6 to 67.0 ± 26.6 after therapy with RTX.
|
31420993 |
2020 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus.
|
31077459 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dsg3 was the commonest positive substrate in pemphigus group (86%) with 100% sensitivity.
|
31211701 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3.
|
31057535 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion.
|
31178865 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment with Pemphigus auto-antibodies results in loss of monolayer integrity and altered localization of desmoglein-3, as well as loss of colocalization with flotillin-2.
|
31247885 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to verify the pathogenic activity of anti-Desmocollin 3 (DSC3) antibodies, we developed an active disease model of pemphigus expressing anti-DSC3 autoantibodies or anti-DSC3 and anti-DSG3 antibodies.
|
31275323 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herpetiformis umfassen.
|
30179341 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA.
|
29740444 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission.
|
29145342 |
2017 |
Pemphigus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ethnic group, age at presentation, initial intercellular antibody titre and initial Dsg 3 antibody levels all had a significant impact on prognosis of pemphigus.
|
24102444 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data indicate that DP phosphorylation at S2849 represents an important mechanism in pemphigus pathogenesis, which, by reversing Ca(2+) insensitivity, promotes Dsg3 depletion.
|
25010392 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations allow us to propose a concept for pemphigus blistering disorders as a "desmosome-remodeling impairment disease" involving a mechanism of Dsg3 nonassembly and depletion from desmosomes through PV immunoglobulin G-activated intracellular signaling events.
|
23257250 |
2013 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
TP did not directly block binding of pemphigus IgG to their target Dsg antigens but prevented PV-IgG-induced inhibition of Dsg3 transinteraction in cell-free (atomic force microscopy) and cell-based (laser tweezer) experiments, indicating stabilization of Dsg3 bonds.
|
19164289 |
2009 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among these, two pathogenic T cell clones induced anti-Dsg3 IgG production and the development of a pemphigus phenotype when adoptively transferred with unprimed B cells from Dsg3(-/-) mice.
|
19155523 |
2009 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction.
|
18641320 |
2008 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris.
|
18586466 |
2008 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis.
|
17431647 |
2007 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity.
|
17428808 |
2007 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, fundamental doubt has been raised towards this monopathogenic view by several independent factors: (1) pemphigus lesions can be induced in Dsg3-knockout (KO) mice; (2) pemphigus sera contain multiple autoantibodies against different adhesion molecules and also cholinergic receptors; (3) experimental inhibition of PV IgG induced acantholysis can be obtained by interference with different signaling cascades regulating both calcium homeostasis and apoptosis; and (4) cholinergic agonists exhibit anti-acantholytic activity both in vitro and in vivo.
|
17101498 |
2006 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1.
|
15841178 |
2005 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alternatively, immunization with a combination of dsg3 protein along with other proteins might be necessary to induce pemphigus disease in adult mice.
|
12653831 |
2003 |
Pemphigus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also showed that the profile of anti-Dsg 1 and/or anti-Dsg 3 autoantibodies is associated with the clinical variant of pemphigus.
|
14646976 |
2003 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles.
|
12496453 |
2003 |