|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dsg3 positive staining in BIOCHIP was observed in 21/21 PV (sensitivity 100%), 13/13 m-PV (sensitivity 100%), 8/8 mc-PV (sensitivity 100%), whereas Dsg3 was negative in all 14 PF sera.
|
30910537 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) usually is associated with autoantibodies against Dsg3 whereas pemphigus foliaceus (PF) patients present autoantibodies against Dsg1.
|
31178865 |
2019 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
All pemphigus vulgaris (PV) and pemphigus foliaceus (PF) IgG and AK23, a monoclonal mouse antibody against Dsg3, caused loss of cell cohesion, cytokeratin retraction and p38MAPK activation.
|
28620161 |
2017 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
To define cut-off values for Dsg1, Dsg3, and BP180, we evaluated 47 serum samples from patients with pemphigus foliaceus (PF), 59 from those with pemphigus vulgaris (PV), 52 from those with bullous pemphigoid (BP), and 995 from healthy individuals.
|
28012821 |
2017 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS).
|
22810308 |
2012 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the use of the ectodomains of Dsg 3 and 1 as target antigens expressed in a human cell line resulted in sensitive and specific ELISA systems for both diagnosis and monitoring of PV and PF.
|
20163452 |
2010 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus is an autoimmune blistering disease caused by IgG autoantibodies that target Dsg1 and Dsg3 in pemphigus foliaceus and pemphigus vulgaris respectively.
|
20178466 |
2009 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune blistering diseases characterized by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively.
|
18219275 |
2008 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Desmoglein 3 is targeted in pemphigus vulgaris while desmoglein 1 is targeted in pemphigus foliaceus and its endemic form, Fogo Selvagem.
|
18838249 |
2008 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We provide evidence that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were equally effective in causing epidermal splitting in human skin and keratinocyte dissociation in vitro.
|
17640963 |
2007 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two Dsg are targeted by pathogenic autoantibodies produced in the course of autoimmune bullous skin diseases, Dsg1 in pemphigus foliaceus (PF), and Dsg3 and Dsg1 in pemphigus vulgaris.
|
17056584 |
2006 |
|
Pemphigus Foliaceus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF), in which autoantibodies bind, respectively, to desmoglein 3 and desmoglein 1, are strongly associated with HLA-class II DR4 and DR14 alleles.
|
12604316 |
2003 |
|
Pemphigus Foliaceus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, some sera of Brazilian PF patients or cases with mixed features of PV and PF also reacted with the intracellular domains of Dsg1 or Dsg3.
|
11154866 |
2001 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The anti-Dsg 1 antibody also was not required, as its presence in PV IgG does not alter the PV-like phenotype in skin organ cultures and because pemphigus foliaceus IgGs produce a distinct phenotype in Dsg3(null) mice.
|
11120754 |
2000 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have analysed the characteristics of the 'pockets' of the susceptibility-associated molecules to PV and PF and we showed that (i) in PV, two kinds of Dsg3 derived peptides may be presented by HLA-DR according to HLA polymorphism (DRB1*0402 or DRB1*14/0406), (ii) the same Dsg1 peptides may be presented by DRB1*0102, DQB1*0404 or DRB1*14 in PF, (iii) the DRB1*14/0406 PV-related molecules may be able to present Dsg1 and Dsg3 peptides thereby providing an explanation for the cases of PV with combined responses to Dsg1 and to Dsg3 which are typified by a muco-cutaneous clinical phenotype.
|
10936030 |
2000 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), respectively.
|
10551416 |
1999 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal desmogleins with molecular weights of 130/140 kDa (Dsg3 or PVA) and 150/160 kDa (Dsg1 or DGI) are recognized by autoantibodies from patients with pemphigus vulgaris (PV) and pemphigus foliaceus (PF), respectively.
|
7547386 |
1995 |
|
Pemphigus Foliaceus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization.
|
8034325 |
1994 |