AGTR1, angiotensin II receptor type 1, 185

N. diseases: 440; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease BEFREE Inhibition of the brain renin-angiotensin system by oral APA inhibitor is at least as effective as oral AT1R blocker to inhibit cardiac dysfunction after MI but without hypotension or renal dysfunction. 30531435 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 AlteredExpression disease BEFREE The increases in AOPP, gp91-phox, and angiotensin II type 1 receptor expression induced by MI were not reduced by E2. 30233413 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 AlteredExpression disease BEFREE The Chinese herbal formula SNT could improve left ventricular systolic function in heart failure after myocardial infarction in rats and decreased the level of Plasma Renin, Angiotensin II, and Aldosterone, as well as downregulating the protein and gene level of ACE and AT1R. 30050591 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease BEFREE The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. 24414230 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations. 23178513 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The AT1R CC genotype conferred a 2.76-fold higher risk of MI compared with the genotype AC and AA. 24167376 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE Polymorphisms in the AT1 gene have been associated with various parameters related to the pathogenesis of cardiovascular diseases and to myocardial infarction. 20537563 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE This study shows an interaction between the use of ACE inhibitors and ACE-G4656C polymorphism, and in low doses also with AGTR1-A1166C polymorphism, in the prevention of MI. 21163865 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population. 19713412 2009
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The risk of MI was reduced in current users of ACE inhibitors with the AGTR1 573CT or CC genotype compared to ACE inhibitors with the AGTR1 573TT genotype (synergy index (SI):0.32; 95% confidence interval (CI): 0.14-0.70). 18347611 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE AGTR1 polymorphism has been reported to associate with hypertension, myocardial infarction (MI), and metabolic traits. 17211857 2007
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ratio = 1.13 per allele, p = 0.005). 17293603 2007
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The authors conducted a population-based, case-control study at Group Health (Seattle, Washington) between 1995 and 1999 to determine whether common haplotypes in the angiotensinogen gene (AGT), the renin gene, the angiotensin-converting enzyme gene, and the angiotensin II receptor type 1 and receptor type 2 genes were associated with the risk of myocardial infarction and stroke among pharmacologically treated hypertensive patients. 17522061 2007
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease LHGDN In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ratio = 1.13 per allele, p = 0.005). 17293603 2007
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE Although there have been several association studies of angiotensin II type 1 receptor (AT1R, A/C1166) gene polymorphism in clinical endpoints such as myocardial infarction (MI), hypertension, aortic stiffness, and left ventricular mass, the relationship between AT1R polymorphism and biventricular function in acute anterior MI has not been studied before. 16998258 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The effect of angiotensin II type-1 receptor gene polymorphisms on doppler blood flow parameters of carotid and brachial arteries in patients with myocardial infarction. 16911325 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease LHGDN Angiotensin receptor blockers may increase risk of myocardial infarction: unraveling the ARB-MI paradox. 16923768 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE Our study suggests that common genetic variations in the AGTR1 gene may affect the risk of MI in Chinese males, and that there might be several functional variants in AGTR1 gene and the combined effect of these variants seemed to have a larger effect on the risk of MI in Chinese males. 15454732 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The angiotensin II type 1 receptor A1166C polymorphism has been associated with increased risks of hypertension and myocardial infarction in several small studies. 12460700 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 AlteredExpression disease BEFREE AT1R blockade is beneficial only when the AT1R was overexpressed, both in reducing the reperfusion-induced arrhythmias and mortality early after MI. 11904535 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported. 11137090 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE An interactive effect on MI risk was found between ACE-DD and AGT1R-AA genotypes (odds ratio [OR]=2, 95% CI= 1-3.9), between ACE-DD and angiotensinogen-TT genotypes (OR = 2.7, 95% CI = 1-7.3), as well as among ACE-DD, angiotensinogen-TT, and AGT1R-AA genotypes (OR=4.8, 95% CI = 1-22.8). 11330506 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting. 11393670 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The genotype distribution of AT1R polymorphism was significantly different between controls and patients, the prevalence of the C allele carriers being higher in patients with MI after the age of 45 than in control individuals (61 vs 45%, p <0.01), leading to an odds ratio (OR) of 2 (CI: 1.2-3.4). 10739375 2000
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE Subjects carrying the ACE DD genotype and AT1R C allele showed a stronger association with myocardial infarction (OR=4.02, P<0.0001). 10731400 2000