Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Inhibition of the brain renin-angiotensin system by oral APA inhibitor is at least as effective as oral AT1R blocker to inhibit cardiac dysfunction after MI but without hypotension or renal dysfunction.
|
30531435 |
2019 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The increases in AOPP, gp91-phox, and angiotensin II type 1 receptor expression induced by MI were not reduced by E2.
|
30233413 |
2018 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The Chinese herbal formula SNT could improve left ventricular systolic function in heart failure after myocardial infarction in rats and decreased the level of Plasma Renin, Angiotensin II, and Aldosterone, as well as downregulating the protein and gene level of ACE and AT1R.
|
30050591 |
2018 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established.
|
24414230 |
2014 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations.
|
23178513 |
2014 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The AT1R CC genotype conferred a 2.76-fold higher risk of MI compared with the genotype AC and AA.
|
24167376 |
2013 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the AT1 gene have been associated with various parameters related to the pathogenesis of cardiovascular diseases and to myocardial infarction.
|
20537563 |
2011 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study shows an interaction between the use of ACE inhibitors and ACE-G4656C polymorphism, and in low doses also with AGTR1-A1166C polymorphism, in the prevention of MI.
|
21163865 |
2011 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.
|
19713412 |
2009 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The risk of MI was reduced in current users of ACE inhibitors with the AGTR1 573CT or CC genotype compared to ACE inhibitors with the AGTR1 573TT genotype (synergy index (SI):0.32; 95% confidence interval (CI): 0.14-0.70).
|
18347611 |
2008 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
AGTR1 polymorphism has been reported to associate with hypertension, myocardial infarction (MI), and metabolic traits.
|
17211857 |
2007 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ratio = 1.13 per allele, p = 0.005).
|
17293603 |
2007 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The authors conducted a population-based, case-control study at Group Health (Seattle, Washington) between 1995 and 1999 to determine whether common haplotypes in the angiotensinogen gene (AGT), the renin gene, the angiotensin-converting enzyme gene, and the angiotensin II receptor type 1 and receptor type 2 genes were associated with the risk of myocardial infarction and stroke among pharmacologically treated hypertensive patients.
|
17522061 |
2007 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ratio = 1.13 per allele, p = 0.005).
|
17293603 |
2007 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Although there have been several association studies of angiotensin II type 1 receptor (AT1R, A/C1166) gene polymorphism in clinical endpoints such as myocardial infarction (MI), hypertension, aortic stiffness, and left ventricular mass, the relationship between AT1R polymorphism and biventricular function in acute anterior MI has not been studied before.
|
16998258 |
2006 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The effect of angiotensin II type-1 receptor gene polymorphisms on doppler blood flow parameters of carotid and brachial arteries in patients with myocardial infarction.
|
16911325 |
2006 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
LHGDN |
Angiotensin receptor blockers may increase risk of myocardial infarction: unraveling the ARB-MI paradox.
|
16923768 |
2006 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that common genetic variations in the AGTR1 gene may affect the risk of MI in Chinese males, and that there might be several functional variants in AGTR1 gene and the combined effect of these variants seemed to have a larger effect on the risk of MI in Chinese males.
|
15454732 |
2004 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin II type 1 receptor A1166C polymorphism has been associated with increased risks of hypertension and myocardial infarction in several small studies.
|
12460700 |
2002 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
AT1R blockade is beneficial only when the AT1R was overexpressed, both in reducing the reperfusion-induced arrhythmias and mortality early after MI.
|
11904535 |
2002 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported.
|
11137090 |
2001 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
An interactive effect on MI risk was found between ACE-DD and AGT1R-AA genotypes (odds ratio [OR]=2, 95% CI= 1-3.9), between ACE-DD and angiotensinogen-TT genotypes (OR = 2.7, 95% CI = 1-7.3), as well as among ACE-DD, angiotensinogen-TT, and AGT1R-AA genotypes (OR=4.8, 95% CI = 1-22.8).
|
11330506 |
2001 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting.
|
11393670 |
2001 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The genotype distribution of AT1R polymorphism was significantly different between controls and patients, the prevalence of the C allele carriers being higher in patients with MI after the age of 45 than in control individuals (61 vs 45%, p <0.01), leading to an odds ratio (OR) of 2 (CI: 1.2-3.4).
|
10739375 |
2000 |
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Subjects carrying the ACE DD genotype and AT1R C allele showed a stronger association with myocardial infarction (OR=4.02, P<0.0001).
|
10731400 |
2000 |