Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE These results encourage the development of DYRK1A inhibitors as drug candidates to treat cognitive deficits associated with DS and AD. 30115750 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE Inhibition of DYRK1A attenuates cognitive dysfunctions in animal models for both DS and Alzheimer's disease (AD). 29985601 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE DYRK1A Protein, A Promising Therapeutic Target to Improve Cognitive Deficits in Down Syndrome. 30332747 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 AlteredExpression disease BEFREE Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. 28377597 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE We found that chronic Dyrk1 inhibition reversed cognitive deficits in 3xTg-AD mice. 28779511 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE DYRK1A hyperactivity appears to contribute to the development of a number of human malignancies and to cognitive deficits observed in Down syndrome and Alzheimer's disease. 28766366 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine kinase DYRK1A, as a candidate for inducing cognitive dysfunction. 24801365 2014
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE MNB/DYRK1A (Minibrain/dual specificity tyrosine phosphorylation-regulated kinase 1A) has possibly been the most extensively studied chromosome 21 gene during the last decade due to the remarkable correlation of its functions in the brain with important DS neuropathologies, such as neuronal deficits, dendrite atrophy, spine dysgenesis, precocious Alzheimer's-like neurodegeneration, and cognitive deficits. 24152332 2014
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE The DYRK1A gene is located within the Down syndrome critical region (DSCR) on human chromosome 21 and current research suggests that overexpression of DYRK1A may be a significant factor leading to cognitive deficits in people with Alzheimer's disease (AD) and Down syndrome (DS). 23173067 2012
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE Together, our results suggest that aberrant Dyrk1A-mediated phosphorylation of the endocytic machinery perturbs synaptic vesicle endocytosis, which may contribute to synaptic dysfunctions and cognitive deficits associated with DS. 21135538 2010
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 AlteredExpression disease BEFREE Genetic-dissection studies carried out with Down syndrome (DS) murine models point to the critical contribution of Dyrk1A overexpression to the motor abnormalities and cognitive deficits displayed in DS individuals. 18940310 2008
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE Among those genes is DYRK1A encoding dual-specificity proline-directed serine/treonine kinase, which, as documented by animal studies, can potentially contribute to cognitive deficits in DS. 17145134 2007
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE In this review we compile and discuss experimental evidences, which support the involvement of MNB/DYRK1A in several neuropathologies and cognitive deficits of Down syndrome. 15068245 2003
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker disease BEFREE Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. 11555628 2001