|
Acromegaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of the p16 protein was lower than in the NFA group than in the CD and acromegaly groups (p = 0.030, p = 0.033, respectively), and E2F1 protein expression was significantly higher in the NFA group than in the CD group (p = 0.025). p73 protein expression in patients with acromegaly was significantly higher (p = 0.031) than that in the CD group.
|
31828584 |
2020 |
|
Parathyroid Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study revealed that ERK1/2 signalling pathway with up-regulation of HRAS, ARAF, and MEK1 genes and up-regulation of positive regulators of cell cycle (CCND1, CDK4, and E2F1) and down-regulation negative regulators of cell cycle (CDKN2A, CDKN2B, and RB1) made highly dysregulated MAPK signalling pathway in parathyroid adenoma.
|
31535356 |
2020 |
|
Blast Phase
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, this work demonstrates that PAs are effective in inhibiting E2F1 TF activity which results in a temporal reduction in BC-CML cell number.
|
31378570 |
2019 |
|
Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The levels of Ki67, LSH, 5-hmC, and E2F1 were all increased in germinal center B-cell lymphomas when compared with those in normal lymph nodes, and LSH was highly expressed in diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphomas (BLs) that were positive for Epstein-Barr virus (EBV) infection, indicating that LSH is linked to EBV infection in DLBCL and BL.
|
30964110 |
2019 |
|
Malignant neoplasm of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, E2F1 has been considered as a potential therapeutic target for this form of skin cancer.
|
31142321 |
2019 |
|
Cholestasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings indicated that TNFα induces hepatic MRP4 expression through activation of the p38-E2F1-Nrf2 signaling pathway in human obstructive cholestasis.
|
31637886 |
2019 |
|
Colorectal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that colorectal tumors from PTEN/E2F-1 double knockout mice and the human colorectal carcinoma cell line HT29 with shRNA-mediated downregulation of PTEN and E2F-1 exhibit hyperactivation of the RAS-MAPK pathway, accumulation of DNA damage and resistance to apoptosis.
|
30206933 |
2019 |
|
Cryptorchidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that an abnormal E2F1 expression caused by multiple copies of E2F1 gene predisposes to the onset of infertility and that the risk further increases if subjects with altered E2F1 copies have stressful conditions, such as heat stress or history of cryptorchidism.
|
30659775 |
2019 |
|
Cytomegalovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we report that HCMV infection of ТНР-1 monocytic leukemic cells considerably elevates E2F1 levels and shifts the balance between the р73 isoforms towards ΔNp73 leading to survival of DOX-treated leukemic cells.
|
30578923 |
2019 |
|
Mental Depression
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no relationship between baseline E2F1 levels and depression severity, response to treatment, presence of psychosis or polarity of depression.
|
30365982 |
2019 |
|
Depressive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no relationship between baseline E2F1 levels and depression severity, response to treatment, presence of psychosis or polarity of depression.
|
30365982 |
2019 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In summary, endothelial DHFR is downregulated by H<sub>2</sub>O<sub>2</sub> transcriptionally via an E2F-dependent mechanism, and that specifically targeting E2F1/2/3a to restore DHFR and eNOS function may serve as a novel therapeutic option for the treatment of hypertension.
|
30571557 |
2019 |
|
Male infertility
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
To evaluate the contribution of copy number variations of E2F1 gene to idiopathic male infertility and the factors influencing expression of this gene.
|
30659775 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells.
|
30914194 |
2019 |
|
Psychotic Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
There was no relationship between baseline E2F1 levels and depression severity, response to treatment, presence of psychosis or polarity of depression.
|
30365982 |
2019 |
|
Epstein-Barr Virus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The levels of Ki67, LSH, 5-hmC, and E2F1 were all increased in germinal center B-cell lymphomas when compared with those in normal lymph nodes, and LSH was highly expressed in diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphomas (BLs) that were positive for Epstein-Barr virus (EBV) infection, indicating that LSH is linked to EBV infection in DLBCL and BL.
|
30964110 |
2019 |
|
Malignant neoplasm of gallbladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
E2F1 and E2F7 differentially regulate KPNA2 to promote the development of gallbladder cancer.
|
30254209 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcriptomic profiling of E2F1 knockout tumors identified a role for E2F1 as a master regulator of a suite of pro-metastatic genes, but also uncovered E2F1 target genes with an unknown role in pulmonary metastasis.
|
31341204 |
2019 |
|
Agenesis of corpus callosum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Altogether, these data show an unexpected role of EZH2 and E2F1 in stimulating expression of genes associated with ACC aggressiveness.
|
31363169 |
2019 |
|
Adrenocortical carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness.
|
31363169 |
2019 |
|
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
E2F1-induced upregulation of long non-coding RNA LMCD1-AS1 facilitates cholangiocarcinoma cell progression by regulating miR-345-5p/COL6A3 pathway.
|
30876691 |
2019 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, E2F1 is abnormally increased in LSCC tissues, and its protein levels were inversely relevant to miR-1205 expression.
|
31801947 |
2019 |
|
Aplasia Cutis Congenita
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Altogether, these data show an unexpected role of EZH2 and E2F1 in stimulating expression of genes associated with ACC aggressiveness.
|
31363169 |
2019 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, we concluded that E2F1-mediated MNX1-AS1-miR-218-5p-SEC61A1 feedback loop contributed to the progression of colon adenocarcinoma.
|
30362161 |
2019 |
|
Human papilloma virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we predict that the induction of expression of RNASEH2A via viral E7 and E2F1 may promote DNA replication and cancer cell proliferation.<b>IMPORTANCE</b> High-risk HPV infections lead to development of cervical cancer.
|
30696738 |
2019 |