Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VRK1 protein levels increase in response to E2F1 and are reduced by retinoblastoma and p16.
|
16547155 |
2006 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromatin immunoprecipitation assays demonstrated that nicotine stimulation caused an increased recruitment of E2F1 and concomitant dissociation of retinoblastoma tumor suppressor protein (Rb) from survivin promoter in A549 cells.
|
16601104 |
2006 |
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Following the subcloning of the promoter regions into a gene reporter system, we found that at least four promoter haplotypes associated with CCND1, E2F1, HDAC1 and RB1 significantly influenced transcriptional activity in an allele-specific manner.
|
16081466 |
2005 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the functional role of the retinoblastoma-E2F1 pathway in regulating telomerase activity in malignant gliomas.
|
16264179 |
2005 |
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These aberrations may reflect the inactivation of retinoblastoma pathway in these tumors which result in the activation of E2F transcription factors, since TAp73 is a known target of E2F1 gene.
|
15138575 |
2004 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
E2F1 function is crucial for responding to loss of proper Rb-mediated growth control to activate p53 and the apoptotic program.
|
15190206 |
2004 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most important, this E2F-1 small interfering RNA also blocks the ability of IGF-I to increase cyclin A accumulation and to hyperphosphorylate RB.
|
14681231 |
2004 |
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ar6pAE2fF (E2F vector) contains the E2F-1 promoter to regulate the expression of the E1a gene in cells with a disregulated retinoblastoma pathway.
|
12788649 |
2003 |
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In LNCaP cells, p53, p21, Bax, and hypophosphorylated retinoblastoma tumor suppressor protein (pRb) levels increased, whereas Bcl2, pRb protein, and E2F transcription factor 1 (E2F1) levels decreased.
|
13130078 |
2003 |
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because XP-E cells deficient in the p48 subunit of the damaged DNA-binding protein are impaired in E2F-1-activated transcription, these results also suggest that the (pRb-regulated) transcription factor E2F-1 does not play an essential role in UV-enhanced expression from the CMV-IE promoter.
|
12870848 |
2003 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expressions of N-myc, cyclin D3, and Wnt10B were downregulated, whereas those of retinoblastoma (RB) and related genes (p107, RB2/p130, p300/CBP, E2F-1, DP-1) as well as others were upregulated.
|
12972807 |
2003 |
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This transformation was associated with an accelerated rate of androgen-independent LNCaP cell proliferation, resistance to apoptosis, hyperphosphorylation of the mitogen-activated protein kinase extracellular signal-regulated kinase and transcriptional repressor protein retinoblastoma, and increased expression of E2F-1 and other 5'-cap-dependent mRNAs, including the G(1) cyclins, c-myc, and caveolin-1.
|
11956106 |
2002 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have reported previously that two key regulators of the cell cycle, the retinoblastoma susceptibility gene product (pRb) and transcription factor E2F1, exhibit altered immunostaining patterns in simian immunodeficiency virus encephalitis (SIVE).
|
11896158 |
2002 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also show that together with the acquired expression of TA-p73, the 'retinoblastoma pathway' is inactivated, and E2F1-target genes including cyclin E and p14(ARF) are activated in hepatocellular carcinoma.
|
11526499 |
2001 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both RB-deficient and E2F1-overexpressing photoreceptor cells expressed rhodopsin, a marker of terminal differentiation.
|
11704831 |
2001 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using immunohistochemistry, patterns of expression of pRB, p16/INK4A, and E2F1 were analyzed in tissue from a cohort of 86 well-characterized patients with nonfamilial retinoblastoma diagnosed at the "Instituto Nacional de Pediatria" in Mexico City.
|
11381373 |
2001 |
Retinoblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells.
|
9187120 |
1997 |
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
E2F-1 activity is regulated by a number of proteins, including the retinoblastoma susceptibility gene product, cyclin-dependent kinases, and their inhibitors, proteins that have been implicated in the control of certain developmental processes.
|
8552097 |
1996 |