E2F3, E2F transcription factor 3, 1871

N. diseases: 98; N. variants: 4
Disease: Bladder Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease BEFREE The expression levels of miR-194-5p and E2F transcription factor 3 (E2F3) were determined by means of quantitative reverse transcription and polymerase chain reaction in BC specimens. 30570877 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 Biomarker disease BEFREE Here, we investigated how Rb is integrated to control bladder cancer progression through E2F3 and p53 regulation. 27922689 2017
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 Biomarker disease BEFREE In summary, our data indicate that E2F3 is a key regulator of cell proliferation in a subset of bladder cancer and the 6p22.3 amplicon is a biomarker of aggressive phenotype in this tumor type. 24231253 2013
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease BEFREE The E2F3 mRNA and protein expression levels were detected in bladder cancer tissues and cell lines, and interestingly, inverse correlations between miR-125b and E2F3 protein level were found in bladder cancer tissues and four E2F3 nonamplified cell lines. 20549700 2011
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 Biomarker disease BEFREE E2F3 and CDKAL1 are candidate genes from the 6p22 region frequently amplified in bladder cancer. 18037967 2008
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease LHGDN E2F3 and CDKAL1 are candidate genes from the 6p22 region frequently amplified in bladder cancer. 18037967 2008
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease BEFREE We first used small interfering RNA technology to confirm the potential importance of E2F3 overexpression in bladder cancer development. 16909110 2007
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease BEFREE In previous studies we have provided evidence that nuclear E2F3 overexpression represents a mechanism that drives the development of human bladder cancer and that determines aggressiveness in human prostate cancer. 16938365 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 Biomarker disease BEFREE Amplification of E2F3 and NM_017774 was analysed by fluorescence in situ hybridization on a bladder cancer tissue microarray composed of 2317 cancer samples. 16953223 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 Biomarker disease BEFREE When considered together with the established role of E2F3 in cell cycle progression, these results suggest that the E2F3 gene represents a candidate bladder cancer oncogene that is activated by DNA amplification and overexpression. 14716298 2004
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease LHGDN E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in a subset of bladder tumors. 15122326 2004
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease LHGDN When considered together with the established role of E2F3 in cell cycle progression, these results suggest that the E2F3 gene represents a candidate bladder cancer oncogene that is activated by DNA amplification and overexpression. 14716298 2004
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.100 AlteredExpression disease BEFREE E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in a subset of bladder tumors. 15122326 2004