E2F3, E2F transcription factor 3, 1871

N. diseases: 98; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 Biomarker disease BEFREE E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. 31839743 2019
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 Biomarker disease BEFREE Characterization of mouse embryonic fibroblasts with this Rb-independent E2F3<sup>LQ</sup> mutation revealed that disrupting the Rb and E2F3 interaction increased cell proliferation, allowed cells to accumulate to higher density, and significantly altered expression of genes involved in metabolism, inflammation, immunity, and response to stress. 28979847 2017
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 AlteredExpression disease BEFREE The results exhibit that Rb expression is lower in patients with bladder tumor, while E2F3 level is high. 27922689 2017
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 AlteredExpression disease LHGDN Further, E2F3 also showed a significant overexpression compared to RB cell lines (p=0.01). 19190782 2009
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 AlteredExpression disease BEFREE Further, E2F3 also showed a significant overexpression compared to RB cell lines (p=0.01). 19190782 2009
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 Biomarker disease BEFREE Our results demonstrated that some copy number changes thought to belong to early (MDM4 gain) or late stage (MYCN and E2F3 gain) of retinoblastoma are already present in retinoma at the same (for MDM4) or at lower (for MYCN and E2F3) copy number variation respect to retinoblastoma. 18785023 2008
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 Biomarker disease LHGDN Our results demonstrated that some copy number changes thought to belong to early (MDM4 gain) or late stage (MYCN and E2F3 gain) of retinoblastoma are already present in retinoma at the same (for MDM4) or at lower (for MYCN and E2F3) copy number variation respect to retinoblastoma. 18785023 2008
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 Biomarker disease BEFREE Gene-specific quantitative multiplex polymerase chain reaction of candidate oncogenes at 1q32.1 (KIF14), 6p22 (E2F3 and DEK), and tumor suppressor genes at 16q22 (CDH11) and 17q21 (NGFR) showed the most common gene gains in RB to be KIF14 in cell lines (80%) and E2F3 in primary tumors (70%). 17099872 2007
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 AlteredExpression disease BEFREE For both bladder and prostate cancer, we have proposed that E2F3 protein overexpression may cooperate with removal of the E2F inhibitor retinoblastoma tumor suppressor protein (pRB) to drive cellular proliferation. 16909110 2007
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 AlteredExpression disease LHGDN Taking into account the proliferation-promoting role of E2F3, implication of E2F3 in bladder and prostate cancer, and the translocation and overexpression of DEK in leukemia, we conclude that either DEK or E2F3 (or both) are targeted by the 6p22 gain in retinoblastoma. 16180235 2006
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 Biomarker disease BEFREE Taking into account the proliferation-promoting role of E2F3, implication of E2F3 in bladder and prostate cancer, and the translocation and overexpression of DEK in leukemia, we conclude that either DEK or E2F3 (or both) are targeted by the 6p22 gain in retinoblastoma. 16180235 2006
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.090 Biomarker disease BEFREE Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. 16007192 2005