|
Acute GVH disease
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Expression of sphingosine-1-phosphate receptor 1 (S1PR1), phosphorylated Akt, mammalian target of rapamycin (mTOR) and Raptor increased, while the phosphorylation level of SMAD3 was decreased in the skin, intestine, lung and liver from obese donor splenocytes-treated aGVHD mice.
|
29088831 |
2017 |
|
Acute GVH disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate the therapeutic efficacy of an S1P1-selective agonist in aGVHD and its possible mechanism of action.
|
25088224 |
2015 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The gene used in the first tier of the algorithm is TSPAN: samples not diagnosed as BE or EA by TSPAN in the first tier are then subjected to a second-tier analysis using ECGF1, followed by a third-tier analysis using SPARC.
|
15788668 |
2005 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
The results showed that EDNRB (endothelin receptor type B), ADRB2 (beta-adrenergic receptor), S1PR1 (sphingosine-1-phosphate receptor 1), P2RY14 (PsY purinoceptor 14), LEPR (leptin-receptor), GHR (growth hormone receptor), PPM1D (protein phosphatase-1D), and GADD45B (growth arrest and DNA-damage-inducible, beta) have high degrees in response to LAC.
|
23111975 |
2012 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Combined DNA methylation and gene expression survival analysis revealed that 4 lncRNAs (AC023824.1, AF186192.1, LINC01354 and WASIR2) and 8 mRNAs (S1PR1, CCDC181, F2RL1, EFS, KLHDC9, MPV17L, GKN2, ITPRIPL1) might act as independent biomarkers for the prognosis of LUAD.
|
31558162 |
2019 |
|
Adult Classical Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of BATF3 in HL cell lines revealed that BATF3 contributed to the transcriptional programme of primary HRS cells, including the upregulation of S1PR1.
|
28878352 |
2018 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma.
|
27061580 |
2016 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry for SphK1 and S1P1 confirmed the overexpression in glioblastoma.
|
24903384 |
2014 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A recent study uncovered a possible explanation for why patients with glioblastoma often have low levels of circulating T cells: The cells become sequestered in the bone marrow in high numbers, and are likely unable to leave because they lack the S1P1 receptor.
|
30185625 |
2018 |
|
Anaplastic carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene.
|
12376462 |
2002 |
|
Anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that XSHG could exert excellent effects on anemia probably through regulating coenzyme A biosynthesis, sphingolipids metabolism and HIF-1α pathways, which was reflected by the increased levels of EPOR, F2, COASY, as well as the reduced protein expression of HIF-1α, SPHK1, and S1PR1.
|
29551975 |
2018 |
|
Anemia, Sickle Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Altogether, we revealed that elevated S1P, coupled with macrophage S1PR1 reciprocally inducing IL-6 expression, is a key signaling network functioning as a malicious, positive, feed-forward loop to sustain inflammation and promote tissue damage in SCD.
|
29401601 |
2018 |
|
Animal Mammary Neoplasms
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene.
|
12376462 |
2002 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of S1PR1-5 in the renal specimens from 24 AAV patients was detected by immunohistochemistry.
|
28206609 |
2017 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Rapamycin may also stabilize artery plaques by preventing apoptosis and S1PR1 in advanced atherosclerosis.
|
30627532 |
2018 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
S1PR1-targeting compounds significantly reduce lesion size in murine models of AS.
|
29134505 |
2018 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Endothelial cell-specific deletion of S1pr1 in the hypercholesterolemic Apoe(-/-) mouse model of atherosclerosis enhanced atherosclerotic lesion formation in the descending aorta.
|
26268607 |
2015 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggests that sphingosine-1-phosphate receptor 1 in macrophages plays an important role in protecting them against apoptosis in vitro and in atherosclerotic plaques in vivo, and delays diet induced atherosclerosis development in <i>Ldlr</i> deficient mice.
|
29244772 |
2017 |
|
Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis.
|
31607926 |
2019 |
|
Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities.
|
22131329 |
2012 |
|
Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our data suggest that targeting S1P and S1P1 may be a potential therapy for arthritis.
|
22992945 |
2012 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We explored the contribution of polymorphisms in the S1PR1 gene to asthma susceptibility.
|
20624651 |
2010 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Autoimmune diseases like asthma and multiple sclerosis (MS) are mediated by the sphingosine-1-phosphate receptor 1 (S1P<sub>1</sub>) to express a variety of symptoms and disease patterns.
|
30409535 |
2018 |
|
Atherosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Endothelial cell-specific deletion of S1pr1 in the hypercholesterolemic Apoe(-/-) mouse model of atherosclerosis enhanced atherosclerotic lesion formation in the descending aorta.
|
26268607 |
2015 |
|
Atherosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Rapamycin may also stabilize artery plaques by preventing apoptosis and S1PR1 in advanced atherosclerosis.
|
30627532 |
2018 |