S1PR1, sphingosine-1-phosphate receptor 1, 1901
N. diseases: 126; N. variants: 6
Source: ALL
Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | Biomarker | phenotype | BEFREE | Suppression of S1PR1 impairs EDV, but contributes to the generation of VM, invasion, and metastasis in vivo and vitro. | 30814488 | 2019 | ||||
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0.070 | Biomarker | phenotype | BEFREE | MDSCs induced by S1PR1-STAT3 in CRC cells formed the premetastatic niche in the liver can promote organ-specific metastasis. | 31534132 | 2019 | ||||
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0.070 | Biomarker | phenotype | BEFREE | Galectin-1 promotes metastasis in gastric cancer through a S1PR1- dependent mechanism, our results indicate that targeting S1PR1 may be a novel strategy to treat GC metastasis. | 30453284 | 2018 | ||||
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0.070 | AlteredExpression | phenotype | BEFREE | Further studies verified a positive correlation between ERO1α and S1PR1, upregulated in metastatic HCC tissues compared with HCC tissues without metastasis. | 30377291 | 2018 | ||||
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0.070 | Biomarker | phenotype | BEFREE | S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β. | 28739604 | 2017 | ||||
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0.070 | Biomarker | phenotype | BEFREE | In conclusion, it was hypothesized that miR‑148a may potentially be used as a molecular agent for the prevention and treatment of invasion and metastasis in ovarian cancer, while S1PR1 may present a promising target for clinical applications. | 26004261 | 2015 | ||||
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0.070 | AlteredExpression | phenotype | BEFREE | Reciprocally, enhanced S1pr1 expression activates STAT3 and upregulates Il6 gene expression, thereby accelerating tumor growth and metastasis in a STAT3-dependent manner. | 21102457 | 2010 |