EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE HRH1 was differentially expressed in adults with asthma vs. controls (p = 0.04), and EDN1 was differentially expressed in children with asthma vs. controls 12-18 years old (p = 0.03). 23448392 2013
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Increase in interleukin 13 and endothelin-1 in serum and bronchoalveolar lavage fluid in OVA-induced asthmatic mice are also decreased by ICA. 31744482 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE We tested a hypothesis that asthma or other atopic diseases are associated with insertion/deletion ACE, M235T angiotensinogen, and TaqI ET-1 gene polymorphisms. 10200023 1999
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Plasma endothelin-1 immunoreactivity in asthmatic children. 11991554 2002
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Literature results on the genetic association of EDN1 in asthma are inconsistent. 17960156 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE Furthermore, erythromycin and clarithromycin inhibited ET-1 expression in bronchoepithelial cells from patients with chronic, stable asthma. 9701415 1998
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. 17470272 2007
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE These are the IL10 -592C>A SNP in the interleukin 10 gene (p=0.036 for eosinophil cell counts), the 4124T>C SNP in EDN1 (p=0.044 for asthma), the 3391C>T SNP in NOS1 with eosinophil cell counts (p=0.0086), and the 5266C>T polymorphism, also in the NOS1 gene, for high IgE levels (p=0.022). 11668616 2001
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE Our findings are consistent with the hypothesis that elevated endothelin-1 levels contribute to subepithelial thickening and highlight this factor as a possible therapeutic target for difficult-to-treat fungal-induced asthma. 30737857 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Targeting EDN1 might represent a novel therapeutic strategy for severe steroid-refractory asthma. 17996929 2007
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease CTD_human MZC is the effective part of MZ and the anti-asthmatic mechanisms ware related to its significant reduction in contents of ET-1, NO, EOS and the damage of lung tissue possibly. 16981460 2006
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease LHGDN Targeting EDN1 might represent a novel therapeutic strategy for severe steroid-refractory asthma. 17996929 2007
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease LHGDN Literature results on the genetic association of EDN1 in asthma are inconsistent. 17960156 2008