|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Vascular responses to endothelin-1 have been shown to be normal or depressed in many models of experimental hypertension, and also in humans with essential hypertension.
|
7496057 |
1995 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Endothelin-1 infusion into humans to obtain pathophysiological plasma levels causes mild hypertension, strong renal vasoconstriction, and sodium retention.
|
7721406 |
1995 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Responses of blood vessels to endothelin-1 may be normal or depressed in many models of experimental hypertension and also in essential hypertension in humans.
|
7768553 |
1995 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1-selective receptor in the arterial intima of patients with hypertension.
|
8125552 |
1994 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.
|
8152482 |
1994 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Endothelin antagonizes the hypotension and potentiates the hypertension induced by clonidine.
|
8440307 |
1993 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Because evidence suggests that endothelin-1 (ET-1) plays a role in the pathogenesis of hypertension, we examined the variability within the ET-1 and the ET(A) receptor genes in patients with essential hypertension (EH).
|
8587478 |
1995 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings demonstrate that endogenous overexpression of preproET-1, accompanied by an elevation of plasma ET-1 concentrations to the levels seen in pathophysiological states, can cause systemic hypertension through the activation of the ETA receptor.
|
8941655 |
1996 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
To establish whether endothelin-1 may play a role in essential hypertension in humans, in whom plasma levels are known to be usually within normal limits, by examining the expression of the endothelin-1 gene in resistance-size arteries of normotensive subjects, and in humans with mild and severe hypertension.
|
9050971 |
1997 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Multivariate analysis demonstrated that only a family history of hypertension (chi-square=7.59, p=0.0059) and ET-1 changes during HG (chi-square=4.23, p=0.0398) were predictive of blood pressure response to HG and that epinephrine and norepinephrine were not.
|
9581734 |
1998 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Increased pulmonary and LV expression of preproET-1 suggests that ET-1 plays a role in mediating the pulmonary hypertension and LV dysfunction characteristic of this model.
|
9595502 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
There is evidence that endothelin-1 may contribute to the pathophysiology of conditions associated with sustained vasoconstriction, such as hypertension and heart failure, vasospastic conditions, such as subarachnoid hemorrhage, and atherogenesis.
|
9607370 |
1998 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury.
|
9787140 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In view of the multiple cardiovascular actions of endothelin-1, there has been much interest in its contribution to the pathophysiology of hypertension.
|
9794709 |
1998 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
To determine whether fetal pulmonary hypertension alters the expression of the genes of the nitric oxide and endothelin-1 pathways, seven fetal lambs (123-126-d gestation) underwent ligation of the ductus arteriosus.
|
9853913 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We therefore looked for irET-1 in the different layers of the wall of human arteries, including renal, gastric, and internal thoracic artery wall, obtained ex vivo from consenting patients with coronary artery disease and/or high blood pressure undergoing surgery, as well as from young organ donors.
|
10069781 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We conclude that enhanced platelet sensitivity to endothelin-1 appears to be a feature of the familial predisposition to hypertension, rather than a nonspecific consequence of high blood pressure.
|
10090337 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
There is much evidence to suggest that endothelin-1 might be involved in the pathogenesis of hypertension, atherosclerosis, and ischemic heart disease.
|
10192234 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Because of the potential role of ET-1 in vascular disorders such as hypertension and atherosclerosis, we investigated the regulation of ET-1 expression by PPAR activators.
|
10473669 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Adrenocorticotrophic hormone-induced hypertension in the rat: effects of the endothelin antagonist bosentan.
|
10474778 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Studies using molecular or pharmacological inhibition of the endothelin system demonstrate that endothelin-1 contributes to the functional and structural changes associated with arterial hypertension and glomerulosclerosis, and that these effects are only in part dependent on blood pressure.
|
10541216 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
|
10669576 |
2000 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Contractile responses of renal arteries to Ang II, endothelin-1 (ET-1), and NA were decreased in dTGR, suggesting hypertension-associated generalized changes in the vascular function rather than a receptor-specific desensitization.
|
11230310 |
2001 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Review of the GDB [Human Genome Database, 1990] reveals that the duplicated region includes the locus EDN2 that encodes endothelin-1, a potent vasoconstrictor, making genetic overdosage of this protein a likely etiology of the pulmonary hypertension.
|
11391651 |
2001 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide.
|
11425780 |
2001 |