Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Assessment of ET plasmatic levels for detection and monitoring of pulmonary hypertension during systemic sclerosis is warranted in larger prospective studies.
ET-1 levels in chronic thromboembolic pulmonary hypertension closely correlated with the hemodynamic and clinical severity of disease in a large cohort of patients.
These data suggest that secreted HIV gp120 proteins induce lung endothelial cell injury and could contribute to the development of HIV-associated pulmonary hypertension.
Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension.
Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.