EDN1, endothelin 1, 1906

N. diseases: 419; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 AlteredExpression phenotype LHGDN Assessment of ET plasmatic levels for detection and monitoring of pulmonary hypertension during systemic sclerosis is warranted in larger prospective studies. 17291632 2007
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype CTD_human Correlation of plasma endothelin-1 levels with pulmonary hypertension after inhaled nitric oxide therapy. 20929026 2010
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype CTD_human Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. 12391278 2002
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 AlteredExpression phenotype LHGDN ET-1 levels in chronic thromboembolic pulmonary hypertension closely correlated with the hemodynamic and clinical severity of disease in a large cohort of patients. 16864942 2006
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype CTD_human Fenfluramine potentiates canine pulmonary vasoreactivity to endothelin-1. 9918753 1999
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype CTD_human Gene expression of endothelin-1 and endothelin receptor a on monocrotaline-induced pulmonary hypertension in rats after bosentan treatment. 20967148 2011
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype CTD_human Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens. 7549228 1995
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype RGD Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension. 20889845 2010
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.530 Biomarker phenotype LHGDN These data suggest that secreted HIV gp120 proteins induce lung endothelial cell injury and could contribute to the development of HIV-associated pulmonary hypertension. 15979050 2005