EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Individuals with T2DM show a misbalance between the synthesis, release, and biological actions of vasodilators and vasoconstrictors such as nitric oxide and endothelin-1. 30849412 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE CONCLUSIONS In conclusion, plasma D-dimer and ET-1 levels on admission independently predict no-reflow after PCI in STEAMI patients with T2DM. 29806659 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Hyperglycemia, hyperinsulinemia, insulin resistance, decrease of glucose transporter, depilation, less activity, flock together, depression, ecchymosis of tongue and tail appearance, the typical diabetic patients "a little more than three" symptoms, as well as the decrease of grip strength, serum cyclic adenosine monophosphate (cAMP)/ cyclic guanosine monophosphate (cGMP) ratio, serum high density lipoprotein-cholesterol (HDL-C) and the increase of serum triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), thromboxane B<sub>2</sub> (TXB<sub>2</sub>)/ 6-keto prostaglandin F1α (6-keto PGF1α) ratio, endothelin-1 (ET-1) levels were found in T2DM group. 29654829 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients. 27752839 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Endothelium-dependent vasorelaxation of the thoracic aorta was significantly decreased and serum levels of endothelin-1 (ET-1), intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were noticably increased in T2DM rats compared with rats without T2DM. 28667102 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Higher basal skeletal muscle expression of endothelin-1 and reduced endothelial nitric oxide phosphorylation (peNOS)/eNOS may contribute to reduced insulin-stimulated blood flow in obese T2D patients. 27789766 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE The authors investigated whether alteration of endothelin-1 and lipid peroxide production and activation of nuclear factor-κB expression were involved in lower limb amputation in type 2 diabetes mellitus patients. 26710051 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE We investigated the molecular mechanisms involved in the effect of FF treatment on plasma levels of ET-1 in type 2 diabetes mellitus patients. 23329136 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Expression of ET-1 in PBMCs may be associated with severity of DR in patients with type 2 DM. 20664700 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1. 19581418 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease RGD Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. 19286964 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE A case-control study was performed to study the genetic association between DR and polymorphic variants of EDN1 (Lys198Asn), LTA (IVS1-80C>A, IVS1-206G>C, IVS1-252A>G), eNOS (Glu298Asp), and ITGA2 (BgI II) in a Chinese population with type 2 diabetes mellitus. 18806884 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease CTD_human Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats. 16387788 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The object of the study was to investigate the share of the polymorphisms I/D ACE, endothelin 1 4127G/A and TNF-beta NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin-dependent diabetes mellitus (NIDDM). 11399938 2001
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with Type 2 diabetes mellitus. 11358684 2001
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Incubation of bovine aortic endothelial cells (BAECs) with erythrocytes from patients with type 2 diabetes induced an increase in endothelin 1 (ET-1) production. 10969841 2000
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE PCR primers for highly polymorphic sites within the EDN1 and NOS3 genes were used to genotype individuals with type 1 or type 2 diabetes with severe or no retinopathy. 10450377 1999