Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The premise of the study is based on recent studies showing that endothelin-1 (ET-1) contributes to the pathophysiology of nephropathy in sickle cell disease (SCD) and that ET<sub>A</sub> receptor blockade improves renal function and protects against renal injury.
|
30144292 |
2019 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, loss of ET-1-dependent natriuresis may account for sodium retention during stress and may predispose retainers to renal diseases such as hypertension and kidney disease.
|
29246686 |
2018 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
It is not known whether elevated serum levels of endothelin-1 indicate future risk of kidney disease in the general population.
|
28698270 |
2017 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In obese subjects, NOS3 4a (P=0.011) had a converse effect to NOS3 894T (P=0.043), and EDN1 8002T (P=0.035) on the prevalence of combined microangiopathy (neuropathy/retinopathy/nephropathy) vs. microangiopathy-negative subjects.
|
21406182 |
2011 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, the frequency of endothelin-1 Lys198Asn polymorphism was investigated with respect to the prevalence of several actual or historical endorgan damages (renal disorder, coronary artery disease, vascular events, vascular damage, and congestive heart failure) in hypertensive patients.
|
18923236 |
2008 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) has been suggested to be a major promoting factor in renal diseases.
|
16943682 |
2006 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies.
|
15855633 |
2005 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
In-vivo interaction of nitric oxide and endothelin.
|
15106802 |
2004 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) has been suggested to be a major disease promoting factor in renal disease.
|
14514737 |
2003 |
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We evaluated the possible relation between plasma endothelin-1 (ET-1) levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy, including nephropathy, neuropathy, and retinopathy in patients with Type 2 diabetes and healthy control group.
|
11358684 |
2001 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Effects of radiocontrast, mannitol, and endothelin on blood pressure and renal damage in the aging male spontaneously hypertensive rat.
|
10399635 |
1999 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, these transgenic lines provide a new blood pressure-independent animal model of ET-1-induced renal pathology leading to renal fibrosis and fatal kidney disease.
|
9077548 |
1997 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Renal disease progression in the rat is associated with a time-dependent upregulation of renal endothelin-1 (ET-1) gene expression and synthesis.
|
8604712 |
1996 |