|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, with the putative causal noncoding variant at the rs9349379 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene.
|
30621952 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nonetheless, the role of ET-1 (<i>EDN1</i>) gene variants on coronary artery disease (CAD) risk remains poorly understood.
|
29654172 |
2018 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Among those without prevalent MI at presentation, ET-1 concentrations were not associated with presence or severity of CAD.
|
30213784 |
2018 |
|
Coronary Artery Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized the existence of a synergistic effect of serum renalase levels and CKD on ET-1 levels in patients with CAD.
|
29743680 |
2018 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Endothelin-1(ET-1) has been implicated in coronary artery disease (CAD) and may be associated with coronary artery ectasia (CAE).
|
27885846 |
2017 |
|
Coronary Artery Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In subgroup analyses, high big ET-1 level was independently associated with ST in patients with acute coronary syndrome (HR 2.29, 95% CI 1.03-5.06, p=0.041), but not in those with stable coronary artery disease (p=0.331), and tended to be associated with older age.
|
28942357 |
2017 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present study firstly suggests that big ET-1 is an independent risk marker of cardiovascular outcomes in patients with stable CAD.
|
28038820 |
2017 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The objective of the study is to determine the autonomic contribution to an increase in ET-1 in response to laboratory stress in patients with CAD.
|
21267513 |
2011 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 (ET-1) promotes vasoconstriction and cell proliferation, and has been implicated in hypertension and coronary artery disease.
|
19672034 |
2009 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Moreover, the frequency of endothelin-1 Lys198Asn polymorphism was investigated with respect to the prevalence of several actual or historical endorgan damages (renal disorder, coronary artery disease, vascular events, vascular damage, and congestive heart failure) in hypertensive patients.
|
18923236 |
2008 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives.
|
18923236 |
2008 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes.
|
17264805 |
2007 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
|
17357073 |
2007 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Endothelin-converting enzyme-1 (ECE-1), the key enzyme responsible for endothelin-1 generation, has been linked to coronary artery disease (CAD).
|
17618613 |
2007 |
|
Coronary Artery Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The present study investigated the association of the ACE I/D polymorphism with plasma concentrations of ET-1 and VP, as well as with renin, angiotensin-II (AT-II) and ACE activity in 98 Caucasian individuals with CAD.
|
12574792 |
2003 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Conversely apparent ET-1, compared with weak or focal eNOS signals, were more frequently seen in coronary segments with concentric severe lesions from CAD but not non-CAD patients.
|
10378508 |
1999 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
We detected irET-1 in the endothelium of all arteries and in the tunica media of internal thoracic artery from most patients with coronary artery disease.
|
10069781 |
1999 |