|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Perinatal exposure to epidermal growth factor (EGF) induces various cognitive and behavioral abnormalities after maturation in non-human animals, and is used for animal models of schizophrenia.
|
31097747 |
2019 |
|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The plasma EGF levels may be a useful biomarker for the early diagnosis, treatment, and prognosis of major psychiatric disorders.
|
22504456 |
2012 |
|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Epidermal growth factor (EGF) and inflammatory markers have been associated with various neuro-psychiatric disorders.
|
28501736 |
2017 |
|
Abnormal myelination
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acoustic Neuroma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
ErbB3 was upregulated in 34%, and ErbB4 is downregulated in NF2-related VS. Of EGF receptor (EGFR) ligands, EGF was upregulated in all NF2-related VS, but none of the sporadic VS (p<0.01), and transforming growth factor alpha and beta-cellulin showed upregulation in 67% of NF2-related VS but not sporadic VS (p=0.02 and p=0.01, respectively).
|
18199957 |
2008 |
|
Acoustic Neuroma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We aimed to determine the role of the growth factors EGF, bFGF, and the hormone, Epo, in promoting such invasive behavior in VS, as well as their mechanisms of action.
|
21178801 |
2011 |
|
Acromicric Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The variant was located in the highly conserved EGF-like calcium-binding domain adjacent to the single reported LTBP3 variant associated with ACMICD.
|
30887145 |
2019 |
|
Actinic keratosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The antiproliferative activity of these hybrids was evaluated on immortalized human keratinocyte (HaCaT) cells stimulated with epidermal growth factor (EGF), an actinic keratosis (AK) model, and on human squamous cell carcinoma (SCC) cells (A431).
|
31075867 |
2019 |
|
Acute Chest Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
At t<sub>1,</sub> IL-2 and EGF levels were still higher in patients with TTC vs. those with ACS (IL-2 4.6 vs. 0.72 pg/ml, p = 0.01; EGF 36.3 vs. 18.5 pg/ml, p = 0.03), while IL-6 serum levels were higher in ACS patients (19.6 vs. 7.35 pg/ml, p = 0.02).
|
29783063 |
2018 |
|
Acute GVH disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Patients with low EGF at day +28 after HCT had an increased risk of death (relative risk 2.3, P=0.02) by 1 year due to transplant-related toxicities, especially aGvHD.
|
28581470 |
2017 |
|
Acute GVH disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
We correlated serum and tissue amphiregulin and epidermal growth factor in patients with acute graft-versus-host disease.
|
30425334 |
2019 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
Twenty-four hours after folic acid induced acute renal injury, creatinine increased from 0.3 +/- 0.03 mg/dl in controls to 2.0 +/- 0.8 mg/dl in folic acid injured kidneys (n = 4, p < 0.03). mRNA for the EGF receptor was increased nearly sevenfold by 24 h, and mRNA for the receptor was increased as early as 1 h following folic acid treatment.
|
11340354 |
2001 |
|
Acute lymphocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
mAbs: Monoclonal antibodies; EF2: elongation factor 2; ITs: Immunotoxins; DT: Diphtheria toxin; PE: Pseudomonas exotoxin; dgA: de-glycosylated A-chain of ricin; rGel: recombinant de-glycosylated form of gelonin; NKC: natural killer cells; HTR: human transferrin receptor; EGF: epidermal growth factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; DAB389: truncated Diphtheria toxin; B-CCL: B-cell chronic lymphocytic leukemia; RCC: renal cell carcinoma; GVHD: Graft-versus-host disease; EGFR: epidermal growth factor receptor; AML: acute myeloid leukemia; Fab: fragment antigen-binding; dsFv: disulfide-stabilized fragment variable; scFv: single-chain fragment variable; B-ALL: B-lineage Acute Lymphoblastic Leukemia; Fv: fragment variable; HCL: hairy cell leukemia; IL-2R: Interleukin-2 receptor; CR: complete response; CLL: chronic lymphocytic leukemia; ATL: adult T-cell leukemia; DARPins: designed Ankyrin repeat proteins; pmol: picomolar; HAMA: human-anti mouse antibody.
|
28282218 |
2017 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using a probe specific for erb B oncogene, which encodes a truncated form of the EGF receptor, we examined RNA and DNA derived from bone marrow and peripheral blood mononuclear cells from three patients with myelodysplastic syndromes (MDS) and one with acute lymphocytic leukemia (ALL), all bearing an abnormal clone in their bone marrow with a similar unbalanced 1;7 translocation.
|
3464613 |
1986 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Renal angiomyolipoma (AML) is a benign but progressive tumor that occasionally requires non-surgical therapy and there appears to be a possibility that epidermal growth factor (EGF) is associated with pathogenesis of renal AML.
|
17685929 |
2007 |
|
Acute pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients were classified into mild (79%) and severe AP (21%) based on organ failure for >or=48 h. Early serum samples were quantitatively assayed for EGF levels.
|
20127414 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This translocation triggered nuclear export of the transcriptional repressor, promyelocytic leukemia zinc finger (PLZF), which we identify as an HB-EGF-C binding protein.
|
14597771 |
2003 |
|
Acute respiratory distress
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that associations of epidermal growth factor gene variants with acute respiratory distress syndrome risk are modified by sex.
|
19010984 |
2009 |
|
Adams Oliver syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.
|
25488668 |
2015 |
|
Adams-Oliver syndrome 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.
|
25488668 |
2015 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Perioperative chemotherapy with or without epidermal growth factor receptor blockade in unselected patients with locally advanced oesophagogastric adenocarcinoma: Randomized phase II study with advanced biomarker program of the German Cancer Society (AIO/CAO STO-0801).
|
29501977 |
2018 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non-smokers with adenocarcinoma.
|
28144970 |
2017 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We performed immunohistochemical analysis on 61 adenocarcinoma tissues for the expression of EGF, EGFR, and cyclin D1 and demonstrated an overexpression in the tumor cells in 51%, 54%, and 62.3%, respectively, whereas normal human pancreas stained negative for all of the three factors.
|
11590324 |
2001 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Immunohistochemical detection of mutated epidermal growth factor receptors in pulmonary adenocarcinoma.
|
21187519 |
2010 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells.
|
23064031 |
2013 |