|
Osteitis Deformans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining and pathological studies were performed on tumor samples, and diagnosis of PD of the nipple was confirmed by expression of proteins characteristic of Paget cells (epidermal growth factor 2 (HER2), androgen receptor (AR), cytokeratin 7 (CK7), cytokeratin 8/18 (CK8/18), and mucin 1 (MUC1)).
|
31720992 |
2020 |
|
Linear atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Comparison between topical recombinant human epidermal growth factor and Aloe vera gel in combination with ablative fractional carbon dioxide laser as treatment for striae alba: A randomized double-blind trial.
|
30614013 |
2020 |
|
Unilateral agenesis of kidney
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The median values were elevated in SFK compared to control for urine PGE<sub>2</sub> [9.1 (n = 57) vs. 5.7 (n = 72), p = 0.009] ng/mgCr and albumin [7.6 (n = 40) vs. 7.0 (n = 41), p = 0.085] µg/mgCr, but not for EGF [20098 (n = 44) vs. 18637 (n = 44), p = 0.746] pg/mgCr.
|
31838197 |
2020 |
|
Paget Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining and pathological studies were performed on tumor samples, and diagnosis of PD of the nipple was confirmed by expression of proteins characteristic of Paget cells (epidermal growth factor 2 (HER2), androgen receptor (AR), cytokeratin 7 (CK7), cytokeratin 8/18 (CK8/18), and mucin 1 (MUC1)).
|
31720992 |
2020 |
|
Papulopustular Rash
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Clinical features and treatment of epidermal growth factor inhibitor-related late-phase papulopustular rash.
|
31803963 |
2020 |
|
Nonproliferative diabetic retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
AH levels of HGF (p = 0.018), Ang2 (p = 0.005) and IL-8 (p = 0.034) were significantly higher, and EGF (p = 0.030) was significantly lower in NPDR subjects.
|
30690929 |
2019 |
|
Bulimia
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-1α, IL-10, EGF, and IFN-γ were altered individuals with anorexia nervosa (AN) and binge eating disorder (BED).
|
31450770 |
2019 |
|
Cerebellar Ataxia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Patients with unknown cerebellar ataxia were screened for autoimmune cerebellar ataxia (ACA)-related antibodies, including glutamic acid decarboxylase 65 (GAD65), delta/notch-like epidermal growth factor-related receptor (Tr/DNER), zinc finger protein 4 (ZIC4), inositol 1,4,5-triphosphate receptor 1 (ITPR1), Homer protein homologue 3 (Homer-3), neurochondrin (NCDN), Purkinje cell antibody 2 (PCA-2) and carbonic anhydrase-related protein VII (CARPVII).
|
31179511 |
2019 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We compared by immunohistochemistry expression of amphiregulin and epidermal growth factor in archived, formalin-fixed, paraffin-embedded intestinal tissues of 48 patients with biopsy-proven gastrointestinal acute graft-versus-host disease to 3 groups: (1) 10 non-hematopoietic cell transplant normal controls, (2) 11 patients with newly diagnosed ulcerative colitis (ulcerative colitis), (3) 8 patients with a clinical diagnosis of acute graft-versus-host disease despite pathologically non-diagnostic biopsies, (4) and 10 cases of cytomegalovirus colitis.
|
30425334 |
2019 |
|
Coughing
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Serum levels of Tumor Necrosis Factor-α (TNF-α), Monocyte chemotactic protein-1 (MCP-1), Vascular endothelial growth factor (VEGF), Epidermal growth factor (EGF), forced expiratory volume-one second (FEV<sub>1</sub>) and respiratory symptoms including; Chest wheeze (CW), night wheeze (NW), night cough (NC) and cough and wheeze during exercise (ECW) were assessed at the baseline (step 0), one and two months after starting treatment (step I and II, respectively).
|
30961947 |
2019 |
|
Dehydration
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Especially, the HAM, processed with the dehydration method, had a higher EGF level than that processed with the fresh-freezing method.
|
31062125 |
2019 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The level of EGF in tears significantly increased in the diabetes with DE group and positively correlated with the CFS and negatively correlated with the Schirmer I test in this group (P < .05).
|
30552892 |
2019 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The level of EGF in tears significantly increased in the diabetes with DE group and positively correlated with the CFS and negatively correlated with the Schirmer I test in this group (P < .05).
|
30552892 |
2019 |
|
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent evidence indicates that epidermal growth factor receptors (EGFRs) are critical pathogenic players in non-neoplastic diseases, including diabetic cardiomyopathy and DR.
|
30221384 |
2019 |
|
Dry Eye Syndromes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The level of EGF in tears significantly increased in the diabetes with DE group and positively correlated with the CFS and negatively correlated with the Schirmer I test in this group (P < .05).
|
30552892 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prevention of clinical and histological signs of MOG-induced experimental allergic encephalomyelitis by prolonged treatment with recombinant human EGF.
|
31100693 |
2019 |
|
Giardiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A putative role for tenascins, present in the Giardia's secretome, is interfering with the host epidermal growth factor.
|
31630757 |
2019 |
|
Focal glomerulosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
That the tyrosine kinase regulation of FSGS mutation binding to actin filaments can occur in cells was shown by phosphorylation on Y4 and Y31 of the K225E after extended exposure of cells to EGF, with a decrease in ACTN4 aggregates in fibroblasts.
|
31664084 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
For the causes of hyperglycemia-induced vascular endothelial dysfunction, the findings point to the key roles of: 1) functional endothelial SGLT2; 2) oxidative stress-induced signalling pathways including mammalian sarcoma virus kinase, the EGF receptor-kinase and protein kinase C; and 3) mitochondrial dysfunction triggered by hyperglycemia was mitigated by an SGLT2 inhibitor in the hyperglycemic mouse aorta vascular organ cultures.
|
30930073 |
2019 |
|
Actinic keratosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The antiproliferative activity of these hybrids was evaluated on immortalized human keratinocyte (HaCaT) cells stimulated with epidermal growth factor (EGF), an actinic keratosis (AK) model, and on human squamous cell carcinoma (SCC) cells (A431).
|
31075867 |
2019 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together these data provide clear-cut in vivo proof of concept for a beneficial role of exogenously administered EGF in MS, that may, therefore, represent a novel therapeutic approach.
|
31100693 |
2019 |
|
Oral Submucous Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further functional enrichment analysis showed these differentially expressed lncRNAs participated in inflammation signaling, Wnt signaling, angiogenesis, CCKR signaling, integrin signaling, PDGF signaling, p53 signaling, and EGF receptor (EGFR) signaling pathways, which contribute to inflammatory and fibroelastic pathogenetic changes of OSF and further malignant progression.
|
31467541 |
2019 |
|
Pituitary Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although targeted therapies such as vascular endothelial growth factor, epidermal growth factor and mTOR inhibitors have also been used to treat refractory PAs, the effectiveness of these targeted therapies is still not known due to a lack of data from randomized prospective trials.
|
31191457 |
2019 |
|
Wheezing
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Serum levels of Tumor Necrosis Factor-α (TNF-α), Monocyte chemotactic protein-1 (MCP-1), Vascular endothelial growth factor (VEGF), Epidermal growth factor (EGF), forced expiratory volume-one second (FEV<sub>1</sub>) and respiratory symptoms including; Chest wheeze (CW), night wheeze (NW), night cough (NC) and cough and wheeze during exercise (ECW) were assessed at the baseline (step 0), one and two months after starting treatment (step I and II, respectively).
|
30961947 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Based on this multi-omics analysis we identified ADGRE5 (alias CD97) - a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors - as a MYC target gene, which is specifically expressed in BL but not in DLBCL regardless of MYC translocation.
|
30953469 |
2019 |