EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells. 11515790 2001
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Therefore, while under normoxic conditions, EGF stimulates the activation of both the PI3K and the MAPK pathways and the induction of VEGF, in glioblastoma cells, hypoxic conditions lead to the suppression of the PI3K/RhoA/C pathway and an exclusive switch to the MAPK pathway. 31698752 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Temozolomide induces the production of epidermal growth factor to regulate MDR1 expression in glioblastoma cells. 25053824 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Finally, glioblastomas may emerge from the microenvironmental outgrowth of more malignant clones in a complex vicious cycle that involves necrosis, hypoxia, growth factor release, angiogenesis and clonal selection; growth signals mediated by activation of epidermal growth factor receptors may precipitate glioblastomas. 9161727 1997
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE We also observed that RhoG is activated by both HGF and EGF, two factors that are thought to be clinically relevant drivers of glioblastoma invasive behavior, and that RhoG is overexpressed in human glioblastoma tumors versus non-neoplastic brain. 22966858 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Thus, our data demonstrate that oncogenic activation of EGFRvIII in GBM is likely maintained by a continuous EGFRwt-EGFRvIII-HB-EGF loop, potentially an attractive target for therapeutic intervention. 24077285 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells. 24012640 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE The atypical protein kinase C inhibitor induced rapid apoptosis in glioblastoma cells expressing EGFRvIII and killed these cells with an IC50 of 16 microM. 12014630 2002
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Two transplantable cell lines of human glioblastoma multiforme GL-3 and GL-5 carried an amplification and overexpression of structurally altered epidermal growth factor (EGF) receptor gene: the 140 kilodalton EGF receptors in these cases exhibited a constitutively expressed tyrosine kinase activity without the ligand. 2168866 1990
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE The epidermal growth factor (EGFR) pathway is frequently activated in glioblastoma but the clinical efficacy of EGFR inhibitors in malignant glioma has been disappointing. 27121290 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Retroviral vectors made with the fusion protein were able to bind peptide antigen and EGFRvIII expressed on the surface of human glioblastoma cells. 10725459 2000
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Primary (de novo) glioblastomas are characterized by amplification/overexpression of the EGF receptor (EGFR) and, less frequently, of the MDM2 gene. 9370234 1997
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells. 12532415 2003
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE We analyzed the differential expression of potential target genes in a glioblastoma cell line in two nested RNAi experimental conditions and one negative control, contrasting expression with EGF stimulation against expression without EGF stimulation. 31438847 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE In analyses of primary GBM tissue and RNA specimens, we found that GRK3 expression is correlated with established criteria for GBM subtyping including expression of EGF receptor, platelet-derived growth factor receptor (PDGFR)α, NF1, PTEN, CDKN2A, and neurofilament. 22086906 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE Direct mTOR inhibitors and EGF receptor (EGFR) inhibitors that block downstream mTOR signaling promote nuclear PML expression in GBMs, and genetic overexpression and knockdown approaches demonstrate that PML prevents mTOR and EGFR inhibitor-dependent cell death. 23440206 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE A mechanism for the upregulation of EGF receptor levels in glioblastomas. 23770238 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Primary (de novo) glioblastomas develop in older patients and are characterized by epidermal growth factor (EGF) receptor amplification/overexpression, p16 deletion, and PTEN mutations, whereas secondary glioblastomas that progressed from low-grade or anaplastic astrocytoma develop in younger patients and frequently contain p53 mutations. 10666371 2000
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Diphtheria toxin-epidermal growth factor fusion protein and Pseudomonas exotoxin-interleukin 13 fusion protein exert synergistic toxicity against human glioblastoma multiforme cells. 14624623 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE According to the prevailing model, NHE9 overexpression leads to an increase in plasma membrane density of epidermal growth factor receptors (EGFRs) which consequently enhances GBM cell proliferation and migration. 31532058 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE In contrast, immunoreactivity for the EGF receptor prevailed in primary glioblastomas (63%) but was rare in secondary glioblastomas (10%). 8864278 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. 22891331 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Lymphocytes were depleted in the classical transcriptional class and in EGF receptor (EGFR)-amplified and homozygous PTEN-deleted glioblastomas. 23864165 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme. 28934307 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. 16697959 2006