EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 Biomarker disease BEFREE While the EGF pathway promotes CSC formation in cervical cancer by inducing SOX2, miR-181a-2-3p/let-7i-5p counteracts the EGF pathway by inhibiting SOX2, thereby reducing the CSC population. 29777148 2018
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 Biomarker disease BEFREE These results suggest that HB‑EGF is an important EGFR ligand in cervical cancer and that cervical cancer cells are the predominant source of HB‑EGF. 28498437 2017
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 Biomarker disease BEFREE The development and metastasis of cervical carcinoma are closely related to epidermal growth factor (EGF) and EGF-1 receptor (EGFR). 24567178 2014
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 Biomarker disease BEFREE Epidermal growth factor (EGF) has been shown to be a potent inducer of EMT in cervical cancer and associated with tumor invasion and metastasis. 23936413 2013
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 Biomarker disease BEFREE Although epidermal growth factor receptor (EGFR) is highly expressed in breast and ovarian tumor tissues, its regulation by the exogenous source of its ligand EGF in human papillomavirus (HPV)-associated cervical cancer remains unclear. 21946890 2012
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 GeneticVariation disease BEFREE These results suggest that EGF functional polymorphism may influence cervical cancer prognosis through an EGF/epidermal growth factor receptor pathway. 21358296 2012
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 AlteredExpression disease BEFREE In conclusion, EGF upregulates NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness. 17894388 2008
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 GeneticVariation disease BEFREE We did not find any evidence that EGF +61 A/G polymorphism was associated with individual susceptibility of cervical cancer. 17316357 2007