Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells.
|
31717527 |
2019 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway.
|
31088266 |
2019 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
According to our results, EGF-modified nanospheres containing bufalin show improved anti-tumor effects on colon cancer in nude mice, but without severe side effects.
|
30596555 |
2019 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer.
|
29515334 |
2018 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, EGF‑ETA was just as potent in HCT116 (KRAS G13D) and SW480 (KRAS G12V) colon cancer cell lines harbouring KRAS hyperactivating mutations when compared to KRAS wild‑type HT29 colon cancer cells.
|
30226622 |
2018 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TU-100 and some of its components and metabolites of these components inhibit tumor progression in two mouse models of colon cancer by blocking downstream pathways of EGF receptor activation.
|
27730672 |
2017 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hydroxytyrosol (HT), a polyphenol of olive oil, downregulates epidermal growth factor (EGFR) expression and inhibits cell proliferation in colon cancer (CC) cells, with mechanisms similar to that activated by the EGFR inhibitor, cetuximab.
|
29137335 |
2017 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.
|
25212605 |
2014 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The EGF-EGFR axis is the main pathway affecting colon cancer's invasive potential, proliferative and migratory ability.
|
24792576 |
2014 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of colon cancer cells (HT29, SW480 and Caco-2) with epidermal growth factor (EGF) caused increased expression of miR-21 and inhibition of AR prevented it.
|
23827854 |
2013 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We reported that berberine significantly inhibited basal level and EGF-stimulated EGFR activation and proliferation in the immorto Min mouse colonic epithelial (IMCE) cells carrying the APC(min) mutation and human colonic carcinoma cell line, HT-29 cells.
|
23457600 |
2013 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At the level of matrix effectors implicated in colon cancer progression we report that pmAb is a potent inhibitor of constitute and EGF-mediated gene expression of certain matrix effectors, such as membrane-type 1 metalloproteinase (MT1-MMP), extracellular metalloproteinases inducer (EMMPRIN), urokinase plasminogen activator (uPA) and syndecan-4.
|
22956286 |
2013 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study revealed that EGF +61 GG genotype was associated with a higher risk of colon cancer in Chinese population.
|
22621366 |
2012 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptors (EGFR) contribute to colonic tumorigenesis in experimental models of colon cancer.
|
21653642 |
2011 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of AR prevented the epidermal growth factor (EGF) or fibroblast growth factor (FGF)-induced migration and invasion of human colon cancer (HT29; KM20) cells by >70% and also inhibited (>80%) the adhesion of the cancer cells to endothelial cells.
|
21642355 |
2011 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receptor down-regulation is the most prominent regulatory system of EGF receptor (EGFR) signal attenuation and a critical target for therapy against colon cancer, which is highly dependent on the function of the EGFR.
|
21646361 |
2011 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor (EGF)-induced proliferation of colon cancer cells plays an important role in colon cancer progression and is mediated by loss of tumor suppressor FOXO3 activity.
|
21639915 |
2011 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we investigated the molecular mechanism by which leptin and VEGF expression are regulated in colon cancer by epidermal growth factor (EGF).
|
19492417 |
2009 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colon cancer-associated MS4A12 is a novel colon-specific component of store-operated Ca2+ (SOC) entry sensitizing cells for epidermal growth factor (EGF)-mediated effects on proliferation and chemotaxis.
|
19781065 |
2009 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line.
|
17222808 |
2007 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitro.
|
16619503 |
2006 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors.
|
16139803 |
2005 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of stomach and colon cancer cell lines with epidermal growth factor stimulated the release of matripatase/HAI-1 complexes.
|
15832373 |
2005 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Data from in vitro studies utilizing colon cancer cell lines suggest that supplemental folic acid or its metabolite 5-methyltetrahydrofolate (5-MTF) attenuates the expression and activation of EGF-receptor (EGFR) as well as proliferation of cells.
|
15353309 |
2004 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Herein, we have demonstrated that EGF enhanced the endogenous expression of MMP-7 in a number of human colon cancer cell lines.
|
15138601 |
2004 |