EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Disease: Carcinoma of bladder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE Importantly, the administration of EGF-toxin to dogs with spontaneous bladder cancer, who had failed or were not eligible for other therapies, resulted in ~30% average tumor reduction after one treatment cycle. 31584195 2020
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE Collectively, our results indicate that EGF may be able to potentiate AR transactivation that leads to enhancing BCa progression, which may help us to develop a better therapeutic approach to treat BCa via targeting both EGF and AR signaling. 24126741 2013
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. 23698120 2013
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE Current results, thus, suggest that EGF promotes bladder cancer cell proliferation via modulation of AR signals. 22922989 2012
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 AlteredExpression disease BEFREE Therefore, we examined the mRNA expression of all four EGF receptors with real-time polymerase chain reaction in biopsies from 88 patients with bladder cancer, where the survival was followed for a median of 38.5 months (range 1-117 months). 16685269 2006
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 AlteredExpression disease BEFREE EGF-R directed bispecific single chain antibodies enhance adenovirus mediated transgene expression and oncolysis in bladder cancer lines. 12050554 2002
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE Members of the epidermal growth factor (EGF) family have been suggested as prognostic markers in patients with bladder cancer. 11507076 2001
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE The CpG islands included exon 5 of PAX6, exon 2 of p16, the 5' end of the deleted in bladder cancer gene, and the 5' end of transmembrane protein containing epidermal growth factor and follistatin domains. 10811126 2000
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 AlteredExpression disease BEFREE There was no marked difference in the expression of the EGF receptor between human bladder cancer cell lines and cultured normal urothelial cells. 10995035 2000
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE Hence, the results obtained suggest a role for either a normal or a mutated overexpressing Ha-ras in up-regulating the surface EGF-R, possibly through an AP-1 site during human bladder carcinoma progression; they also highlight the potential that EGF may have in cooperating with this EGF-R up-regulation to help mediate enhanced tumor growth. 1868471 1991
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.100 Biomarker disease BEFREE EGF stimulates anchorage-independent growth of a human bladder carcinoma cell line (KU1) with an amplified and over-expressed EGF receptor gene. 2606569 1989