|
Malignant neoplasm of lung
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor receptor expression in human lung cancer cell lines.
|
2830015 |
1988 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Simultaneous amplification of epidermal growth factor-receptor and multidrug-resistance genes in a newly. Established human lung cancer cell line.
|
2018357 |
1991 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The type III EGFR deletion mutant, expressed in some cases of NSCLC, may be a molecularly defined, tumor-specific antigen in lung cancer.
|
8391918 |
1993 |
|
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung.
|
7683573 |
1993 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have determined the average gene copy numbers (AGCN) of the erbB-1 gene, encoding the epidermal growth factor receptor (EGF-R), the erbB-2 and the erbB-3 genes in breast, ovarian, oral, and lung cancer tissue by using double-differential PCR (ddPCR).
|
7607571 |
1995 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
The LC with SSCP p53 molecular abnormalities have a significantly higher EGFR content (P < 0.001), SPF (P < 0.007), D.I.
|
9498104 |
1998 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer. Lung Cancer Study Group.
|
10190311 |
1999 |
|
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To test this hypothesis, we studied by immunohistochemistry the expression of EGFR and TGF-alpha in primary non small cell lung cancers.
|
10963846 |
2000 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Over-expression of truncated epidermal growth factor receptor (EGFR) occurs in a variety of malignancies including glioblastoma multiforme, breast and lung cancer.
|
11355942 |
2001 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Evidence for the epidermal growth factor receptor as a target for lung cancer prevention.
|
11801540 |
2002 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor family in lung cancer and premalignancy.
|
11894009 |
2002 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results demonstrate a role of Stat3 in transducing survival signals downstream of tyrosine kinases such as Src, EGF-R, and c-Met, as well as cytokines such as IL-6, in human nonsmall cell lung cancers.
|
12833138 |
2003 |
|
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
EGFR and Her-2 are overexpressed in lung cancers and have, therefore, been chosen as preferred targets for novel therapies.
|
12867057 |
2003 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications.
|
15604253 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because the ErbB receptors play an important role in lung cancer progression, we analyzed the expression of epidermal growth factor receptor (EGFR), phosphorylated EGFR, transforming growth factor alpha (TGFalpha), and HER2-neu as potential prognostic factors in stage I NSCLC.
|
14734462 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overexpression of the epidermal growth factor receptor (EGFR) has been identified as a common component of various cancer types including lung cancer.
|
14534727 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
The recent identification of somatic mutations in the epidermal growth factor receptor (EGFR)-tyrosine kinase (TK) domain of tumor samples from patients with non-small-cell lung cancer (NSCLC) that portend robust response to small-molecule inhibitors of EGFR TK is a watershed event in the fields of lung cancer genetics and therapeutic agents.
|
15638956 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Collectively, these data show that adenocarcinomas from never smokers comprise a distinct subset of lung cancers, frequently containing mutations within the TK domain of EGFR that are associated with gefitinib and erlotinib sensitivity.
|
15329413 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan.
|
15623594 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The recent finding that mutations in EGFR predict the response of lung cancers to therapies that target the TK domain of the gene product has generated considerable interest.
|
15464447 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
The biology of epidermal growth factor receptor in lung cancer.
|
15217963 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations were identified in the tyrosine kinase domain of the EGFR gene in eight of nine patients with gefitinib-responsive lung cancer, as compared with none of the seven patients with no response (P<0.001).
|
15118073 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this article, we review the role of EGFR in lung cancer, as well as preclinical and clinical data on strategies to interfere with EGFR signaling alone or in combination with chemotherapy, radiation, or both.
|
15217533 |
2004 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1alpha expression.
|
15363541 |
2004 |