|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This article principally reviews previous investigations of the role of the epidermal growth factor receptor in bladder cancer and examines methods of detection, the correlation between EGFr status and known prognostic indicators and the value of assessing EGFr status in predicting clinical outcome in patients with bladder cancer.
|
1357809 |
1992 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the search for sensitive and specific tumor markers for bladder carcinoma, expression of various oncogenes and gene products (such as c-erb B-2, p53) and epidermal growth factor receptor merits particular attention.
|
1498153 |
1992 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that epidermal growth factor receptor amplification and/or gene rearrangement occurs infrequently in bladder cancer.
|
1729545 |
1992 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, the results obtained suggest a role for either a normal or a mutated overexpressing Ha-ras in up-regulating the surface EGF-R, possibly through an AP-1 site during human bladder carcinoma progression; they also highlight the potential that EGF may have in cooperating with this EGF-R up-regulation to help mediate enhanced tumor growth.
|
1868471 |
1991 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the c-erbB-2 gene product and the epidermal growth factor receptor (EGF-R) was investigated in 54 cases of human bladder cancer immunohistologically and by Western blot analysis.
|
1988741 |
1991 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Southern blot analysis of 6 human bladder carcinoma cell lines revealed amplification of the epidermal growth factor receptor (EGFR) gene in the KU1 cell line.
|
2606569 |
1989 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
No consensus as to the involvement of the epidermal growth factor receptor (EGF-R) in colorectal carcinomas has yet been attained, although they are assumed to play a role in the metastasis to lymph nodes and recurrence of breast carcinoma and bladder carcinoma invasion.
|
7781795 |
1995 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Epidermal-growth-factor-receptor expression is associated with rapid tumor proliferation in bladder cancer.
|
8181854 |
1994 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our objective was to develop a methodology that extends previous investigations on relative and absolute quantitation of the epidermal growth factor receptor (EGFR) in dual parameter analysis in vitro on human bladder cancer cell lines [3].
|
8844105 |
1996 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of transforming growth factor alpha and epidermal growth factor receptor in human bladder cancer.
|
10463465 |
1999 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients.
|
11507076 |
2001 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor targeting of replication competent adenovirus enhances cytotoxicity in bladder cancer.
|
12050554 |
2002 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular we focus on how H-Ras, RalA/B and RhoGDI2, a regulator of Rho family members, participate in bladder cancer progression and how their participation may be related to other molecules associated with bladder cancer progression, such as epidermal growth factor receptor, p53 and PTEN (phosphatase and tensin homologue deleted on chromosome 10).
|
14532839 |
2003 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeted therapy against epidermal growth factor receptor has become one of the primary focuses of the genitourinary SPORE in bladder cancer.
|
15300150 |
2004 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
RT-PCR specific for Tenascin C and EGFR was performed on RNAs extracted from blood samples of 60 patients affected by colon or bladder cancer.
|
16211285 |
2005 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using clinical specimens from different stages of bladder cancer, immunohistochemical staining was performed to determine if Id-1 expression was positively associated with tumour staging and EGFR expression.
|
16525633 |
2006 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In comparison to that the blockade of the expression of hTERT using 2 different siRNAs was accompanied by the down-regulation of the oncogenes FOS-like antigen 1 (FOSL1) and epidermal growth factor receptor (EGFR), known to be overexpressed in BCa.
|
16615118 |
2006 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, prognostic significance of HER1 and HER2 receptors in bladder cancer is controversial and the effect of the expression of different combinations of these receptors on patient survival is not well understood.
|
16685269 |
2006 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The kinase domain found within exons 18 to 21 of the EGFR from 11 bladder cancer cell lines and 75 patient tumors were subjected to automated sequencing.
|
16899617 |
2006 |
|
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cell-surface HER1/EGFR expression was present in all seven bladder cancer cell lines.
|
17346275 |
2007 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The kinase domain of EGFR (exons 18-21) from 11 bladder cancer cell lines as well as from 75 patient tumors was analyzed by automated sequencing.
|
17690890 |
2007 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor status and the response of bladder carcinoma cells to erlotinib.
|
17707060 |
2007 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This observation suggests a potential role for nuclear EGFR in bladder cancer.
|
17909029 |
2007 |
|
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest modified bladder cancer risk and survival associated with genetic variation in the EGFR pathway.
|
19372140 |
2009 |
|
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy.
|
19671845 |
2009 |